Impact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorGomes Filho, Fernando Ferreira-
Autor(es): dc.creatorde Andrade, Luis Gustavo Modelli-
Autor(es): dc.creatorAmaro, João Luiz-
Autor(es): dc.creatorBarreti, Pasqual-
Autor(es): dc.creatorYamamoto, Hamilto Akihissa-
Autor(es): dc.creatorGuerra, Rodrigo-
Autor(es): dc.creatorOrdones, Flavio Vasconcelos-
Autor(es): dc.creatorPajolli, Pedro Rochetti-
Autor(es): dc.creatordos Santos, Daniela Cristina-
Autor(es): dc.creatorReis, Leonardo Oliveira-
Autor(es): dc.creatorKawano, Paulo Roberto-
Data de aceite: dc.date.accessioned2025-08-21T22:48:48Z-
Data de disponibilização: dc.date.available2025-08-21T22:48:48Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.transproceed.2021.09.016-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222861-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222861-
Descrição: dc.descriptionBackground: A low supply of donated organs led to the expansion of criteria for kidney transplantation (KT), and the impact on late glomerular function rates (eGFR) is still uncertain. This study aimed to correlate the histologic findings at time-zero biopsy (TzB) with the final eGFR, to identify criteria that could help achieve a more thorough preimplantation evaluation of the organ. Methods: Records from 395 adult deceased KTs were reviewed. TzBs were analyzed considering histologic criteria by compartment (vascular, interstitial, tubular, and inflammatory) and correlated with the eGFR after 1 year. Results: Among donors, 56.9% were men (mean age 39 years), with the main causes of death being brain trauma (44.2%) and stroke (46.0%). Histologic analysis of TzB revealed 6.0% of glomerulosclerosis; 18.8% presenting vascular alterations; interstitial fibrosis in 54.6%; tubular changes in 76.9%, and nonspecific inflammatory infiltrate in 2.3%. Linear regression analysis showed that the main histologic findings that had impact in the eGFR were interstitial fibrosis (P = .000), followed by tubular alterations (P = .036) and glomerulosclerosis (P = .008). Conclusions: Histologic variables like interstitial fibrosis and tubular alterations show the most significant negative correlation with final eGFR. The effect of glomerulosclerosis may not be as important as formerly suggested in the literature.-
Descrição: dc.descriptionUrology Department University of São Paulo State-
Descrição: dc.descriptionNephrology Department University of São Paulo State-
Descrição: dc.descriptionPathology Department University of São Paulo State-
Descrição: dc.descriptionUrology Department Unicamp-
Idioma: dc.languageen-
Relação: dc.relationTransplantation Proceedings-
???dc.source???: dc.sourceScopus-
Título: dc.titleImpact of Time-Zero Biopsy on the Outcome of Transplanted Kidneys-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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