Functional consequences of lead and mercury exposomes in the heart

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidad de la República-
Autor(es): dc.contributorUniversidad Católica de Chile-
Autor(es): dc.contributorUniversidad de Sevilla-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Queensland-
Autor(es): dc.contributorThe Institute for Molecular Medicine-
Autor(es): dc.creatorFerreira, Gonzalo-
Autor(es): dc.creatorSantander, Axel-
Autor(es): dc.creatorChavarría, Luisina-
Autor(es): dc.creatorCardozo, Romina-
Autor(es): dc.creatorSavio, Florencia-
Autor(es): dc.creatorSobrevia, Luis-
Autor(es): dc.creatorNicolson, Garth L.-
Data de aceite: dc.date.accessioned2025-08-21T15:21:59Z-
Data de disponibilização: dc.date.available2025-08-21T15:21:59Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mam.2021.101048-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222852-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222852-
Descrição: dc.descriptionLead and mercury are heavy metals that are highly toxic to life forms. There are no known physiological processes that require them, and they do not have a particular threshold concentration to produce biologic damage. They are non-biodegradable, and they slowly accumulate in the environment in a dynamic equilibrium between air, water, soil, food, and living organisms. Their accumulation in the environment has been increasing over time, because they were not banned from use in anthropogenic industrial production. In their +2 cationic state they are powerful oxidizing agents with the ability to interfere significantly with processes that require specific divalent cations. Acute or chronic exposure to lead and mercury can produce multisystemic damage, especially in the developing nervous systems of children and fetuses, resulting in variety of neurological consequences. They can also affect the cardiovascular system and especially the heart, either directly through their action on cardiomyocytes or indirectly through their effects on innervation, humoral responses or blood vessel alterations. For example, heart function modified by these heavy metals are heart rate, contraction, excitability, and rhythm. Some cardiac molecular targets have been identified and characterized. The direct mechanisms of damage of these heavy metals on heart function are discussed. We conclude that exposome to these heavy metals, should be considered as a major relevant risk factor for cardiac diseases.-
Descrição: dc.descriptionAgencia Nacional de Investigación e Innovación-
Descrição: dc.descriptionCA Technologies-
Descrição: dc.descriptionComisión Sectorial de Investigación Científica-
Descrição: dc.descriptionFondo Nacional de Desarrollo Científico y Tecnológico-
Descrição: dc.descriptionFP7 International Cooperation-
Descrição: dc.descriptionRijksuniversiteit Groningen-
Descrição: dc.descriptionUniversity of South Alabama-
Descrição: dc.descriptionLaboratory of Ion Channels Biological Membranes and Cell Signaling Department of Biophysics Faculty of Medicine Universidad de la República, Gral. Flores, CP 11800-
Descrição: dc.descriptionCellular and Molecular Physiology Laboratory (CMPL) Department of Obstetrics Division of Obstetrics and Gynaecology Universidad Católica de Chile, 8330024-
Descrição: dc.descriptionDepartment of Physiology Faculty of Pharmacy Universidad de Sevilla-
Descrição: dc.descriptionMedical School (Faculty of Medicine) São Paulo State University (UNESP)-
Descrição: dc.descriptionUniversity of Queensland Centre for Clinical Research (UQCCR) Faculty of Medicine and Biomedical Sciences University of Queensland, QLD 4029-
Descrição: dc.descriptionDepartment of Pathology and Medical Biology University of Groningen University Medical Center Groningen-
Descrição: dc.descriptionDepartment of Molecular Pathology The Institute for Molecular Medicine, 16731 Gothard St. Huntington Beach-
Descrição: dc.descriptionMedical School (Faculty of Medicine) São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationMolecular Aspects of Medicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCardiac-
Palavras-chave: dc.subjectExposure-
Palavras-chave: dc.subjectIntoxication-
Palavras-chave: dc.subjectLead-
Palavras-chave: dc.subjectMercury-
Palavras-chave: dc.subjectPoisoning-
Título: dc.titleFunctional consequences of lead and mercury exposomes in the heart-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.