Green and chemical silver nanoparticles and pomegranate formulations to heal infected wounds in diabetic rats

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorApis Flora Industrial e Comercial Ltda-
Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.creatorScappaticci, Renan Aparecido Fernandes-
Autor(es): dc.creatorBerretta, Andresa Aparecida-
Autor(es): dc.creatorTorres, Elina Cassia-
Autor(es): dc.creatorBuszinski, Andrei Felipe Moreira-
Autor(es): dc.creatorFernandes, Gabriela Lopes-
Autor(es): dc.creatorDos Reis, Thaila Fernanda-
Autor(es): dc.creatorde Souza-Neto, Francisco Nunes-
Autor(es): dc.creatorGorup, Luiz Fernando-
Autor(es): dc.creatorde Camargo, Emerson Rodrigues-
Autor(es): dc.creatorBarbosa, Debora Barros-
Data de aceite: dc.date.accessioned2025-08-21T16:50:44Z-
Data de disponibilização: dc.date.available2025-08-21T16:50:44Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/antibiotics10111343-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222842-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222842-
Descrição: dc.descriptionInfected cutaneous ulcers from diabetic rats with Candida albicans and Streptococcus aureus were treated with spray formulations containing green silver nanoparticles (GS), chemical silver nanoparticles (CS), or pomegranate peel extract (PS). After wound development and infection, the treatments were performed twice per day for 14 days. The wound healing was analyzed on days 2, 7, and 14 through the determination of CFUs, inflammatory infiltrate, angiogenesis, fibroplasia, myeloperoxidase, and collagen determination. Expressive improvement in wound healing was noted using both silver nanoparticles for 7 days. All the treatments were superior to controls and promoted significant S. aureus reduction after 14 days. CS presented better anti-inflammatory results, and GS and CS the highest number of fibroblasts. Despite the techniques’ limitations, GS and CS demonstrated considerable potential for managing infected wounds, especially considering no early strategies prior to the drugs, such as the debridement of these wounds, were included.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Research Development & Innovation Apis Flora Industrial e Comercial Ltda-
Descrição: dc.descriptionDepartment of Chemistry Federal University of São Carlos-
Descrição: dc.descriptionDepartment of Dental Materials and Prosthodontics School of Dentistry São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2016/04230-9-
Idioma: dc.languageen-
Relação: dc.relationAntibiotics-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectNanoparticles-
Palavras-chave: dc.subjectPunica granatum-
Palavras-chave: dc.subjectSilver-
Palavras-chave: dc.subjectStaphylococcus aureus-
Palavras-chave: dc.subjectWound healing-
Título: dc.titleGreen and chemical silver nanoparticles and pomegranate formulations to heal infected wounds in diabetic rats-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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