Searching for bioactive compounds from Solanaceae: lethal and sublethal toxicity to Spodoptera frugiperda and untargeted metabolomics approaches

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Autor(es): dc.contributorUniversidade Federal de Lavras (UFLA)-
Autor(es): dc.contributorAgricultural Research and Rural Extension Company of Santa Catarina (EPAGRI/CEPAF)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorLima, Andreísa Fabri-
Autor(es): dc.creatordo Prado Ribeiro, Leandro-
Autor(es): dc.creatorGonçalves, Gabriel Luiz Padoan-
Autor(es): dc.creatorMaimone, Naydja Moralles-
Autor(es): dc.creatorGissi, Danilo Soares-
Autor(es): dc.creatorde Lira, Simone Possedente-
Autor(es): dc.creatorVendramim, José Djair-
Data de aceite: dc.date.accessioned2025-08-21T21:39:07Z-
Data de disponibilização: dc.date.available2025-08-21T21:39:07Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s10340-021-01453-5-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222810-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222810-
Descrição: dc.descriptionThe fall armyworm, Spodoptera frugiperda (J.E. Smith) (Lepidoptera: Noctuidae), is a major pest of maize crops and others row crops on the American continent, and this pest has spread to Africa and Asia. Such lepidopteran pest presents resistant populations to synthetic insecticides and to Bacillus thuringiensis (Bt) toxins and, consequently, new (bio) insecticides with distinct modes of action are required. In order to search for derivatives from Solanaceae as a potential source of bioactive compounds, a screening of 38 ethanolic extracts were prepared from 25 Solanaceae species. Using dietary exposure assessment, the ethanolic extracts from leaves of Acnistus arborescens (L.) Schltdl. and Datura stramonium L. were the most promising derivatives. A bioguided fractionation was performed with both plant species. The A. arborescens dichloromethane fraction was the most active, causing sublethal (growth inhibition) and lethal toxicity. Thus, this fraction was submitted to another fractionation procedure resulting in three subfractions (dichloromethane, ethyl acetate and methanol) that were tested against S. frugiperda caterpillars. All subfractions lead to significant sublethal effects, however, without significant mortality. The chemical diversity in the subfractions of A. arborescens was assessed through untargeted approaches, such as molecular networking and the in silico annotation tool NAP, by which two withanolides glycosides were annotated: (22R)-1-Oxo-3beta-(beta-D-glucopyranosyloxy)-14,20,22,27-tetrahydroxyergosta-5,24-diene-26-oic acid delta-lactone and withanoside XI. Therefore, derivatives of Solanaceae present promising compounds that may be useful in the framework of S. frugiperda integrated pest management. In addition, metabolomics is an innovative alternative and powerful approach to facilitate the putative identification of compounds in studies of natural products.-
Descrição: dc.descriptionDepartment of Entomology Lavras Federal University (UFLA)-
Descrição: dc.descriptionResearch Center for Family Agriculture Agricultural Research and Rural Extension Company of Santa Catarina (EPAGRI/CEPAF), Rua Ferdinando Ricieri Tusset S/N, Bairro São Cristóvão, Caixa Postal 791-
Descrição: dc.descriptionDepartment of Exact Sciences “Luiz de Queiroz” College of Agriculture (USP/ESALQ) University of São Paulo-
Descrição: dc.descriptionDepartment of Botany São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Entomology and Acarology “Luiz de Queiroz” College of Agriculture (USP/ESALQ) University of São Paulo-
Descrição: dc.descriptionDepartment of Botany São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationJournal of Pest Science-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcnistus arborescens-
Palavras-chave: dc.subjectBotanical insecticides-
Palavras-chave: dc.subjectChromatographic procedures-
Palavras-chave: dc.subjectDatura stramonium-
Palavras-chave: dc.subjectFall armyworm-
Palavras-chave: dc.subjectWithanolides-
Título: dc.titleSearching for bioactive compounds from Solanaceae: lethal and sublethal toxicity to Spodoptera frugiperda and untargeted metabolomics approaches-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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