A duplicated copy of id2b is an unusual sex-determining candidate gene on the Y chromosome of arapaima (Arapaima gigas)

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Autor(es): dc.contributorUniversity of Wuerzburg-
Autor(es): dc.contributorTexas State University-
Autor(es): dc.contributorUniversité de Toulouse-
Autor(es): dc.contributorLPGP-
Autor(es): dc.contributorand Swiss Institute of Bioinformatics-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorGenotoul-
Autor(es): dc.contributorIGB-
Autor(es): dc.contributorHiroshima University-
Autor(es): dc.contributorUniversity Hospital-
Autor(es): dc.creatorAdolfi, Mateus C.-
Autor(es): dc.creatorDu, Kang-
Autor(es): dc.creatorKneitz, Susanne-
Autor(es): dc.creatorCabau, Cédric-
Autor(es): dc.creatorZahm, Margot-
Autor(es): dc.creatorKlopp, Christophe-
Autor(es): dc.creatorFeron, Romain-
Autor(es): dc.creatorPaixão, Rômulo V.-
Autor(es): dc.creatorVarela, Eduardo S.-
Autor(es): dc.creatorde Almeida, Fernanda L.-
Autor(es): dc.creatorde Oliveira, Marcos A.-
Autor(es): dc.creatorNóbrega, Rafael H.-
Autor(es): dc.creatorLopez-Roques, Céline-
Autor(es): dc.creatorIampietro, Carole-
Autor(es): dc.creatorLluch, Jérôme-
Autor(es): dc.creatorKloas, Werner-
Autor(es): dc.creatorWuertz, Sven-
Autor(es): dc.creatorSchaefer, Fabian-
Autor(es): dc.creatorStöck, Matthias-
Autor(es): dc.creatorGuiguen, Yann-
Autor(es): dc.creatorSchartl, Manfred-
Data de aceite: dc.date.accessioned2025-08-21T23:03:45Z-
Data de disponibilização: dc.date.available2025-08-21T23:03:45Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-021-01066-z-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222809-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222809-
Descrição: dc.descriptionArapaima gigas is one of the largest freshwater fish species of high ecological and economic importance. Overfishing and habitat destruction are severe threats to the remaining wild populations. By incorporating a chromosomal Hi-C contact map, we improved the arapaima genome assembly to chromosome-level, revealing an unexpected high degree of chromosome rearrangements during evolution of the bonytongues (Osteoglossiformes). Combining this new assembly with pool-sequencing of male and female genomes, we identified id2bbY, a duplicated copy of the inhibitor of DNA binding 2b (id2b) gene on the Y chromosome as candidate male sex-determining gene. A PCR-test for id2bbY was developed, demonstrating that this gene is a reliable male-specific marker for genotyping. Expression analyses showed that this gene is expressed in juvenile male gonads. Its paralog, id2ba, exhibits a male-biased expression in immature gonads. Transcriptome analyses and protein structure predictions confirm id2bbY as a prime candidate for the master sex-determiner. Acting through the TGFβ signaling pathway, id2bbY from arapaima would provide the first evidence for a link of this family of transcriptional regulators to sex determination. Our study broadens our current understanding about the evolution of sex determination genetic networks and provide a tool for improving arapaima aquaculture for commercial and conservation purposes.-
Descrição: dc.descriptionJulius-Maximilians-Universität Würzburg-
Descrição: dc.descriptionDevelopmental Biochemistry Biocenter University of Wuerzburg, Am Hubland-
Descrição: dc.descriptionThe Xiphophorus Genetic Stock Center Department of Chemistry and Biochemistry Texas State University, San Marcos-
Descrição: dc.descriptionBiochemistry and Cell Biology Biocenter University of Wuerzburg, Am Hubland-
Descrição: dc.descriptionSigenae GenPhySE INRAE ENVT Université de Toulouse-
Descrição: dc.descriptionMIAT INRA Université de Toulouse, Chemin de Borde Rouge-
Descrição: dc.descriptionINRAE LPGP-
Descrição: dc.descriptionDepartment of Ecology and Evolution University of Lausanne and Swiss Institute of Bioinformatics-
Descrição: dc.descriptionEmbrapa Amazônia Ocidental-
Descrição: dc.descriptionEmbrapa Pesca E Aquicultura-
Descrição: dc.descriptionReproductive and Molecular Biology Group Department of Morphology Institute of Biosciences UNESP-
Descrição: dc.descriptionGeT-PlaGe INRAE Genotoul-
Descrição: dc.descriptionLeibniz-Institute of Freshwater Ecology and Inland Fisheries IGB, Müggelseedamm 301 & 310-
Descrição: dc.descriptionAmphibian Research Center Hiroshima University-
Descrição: dc.descriptionComprehensive Cancer Center Mainfranken University Hospital-
Descrição: dc.descriptionReproductive and Molecular Biology Group Department of Morphology Institute of Biosciences UNESP-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleA duplicated copy of id2b is an unusual sex-determining candidate gene on the Y chromosome of arapaima (Arapaima gigas)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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