
Atenção:
O eduCAPES é um repositório de objetos educacionais, não sendo responsável por materiais de terceiros submetidos na plataforma. O usuário assume ampla e total responsabilidade quanto à originalidade, à titularidade e ao conteúdo, citações de obras consultadas, referências e outros elementos que fazem parte do material que deseja submeter. Recomendamos que se reporte diretamente ao(s) autor(es), indicando qual parte do material foi considerada imprópria (cite página e parágrafo) e justificando sua denúncia.
Caso seja o autor original de algum material publicado indevidamente ou sem autorização, será necessário que se identifique informando nome completo, CPF e data de nascimento. Caso possua uma decisão judicial para retirada do material, solicitamos que informe o link de acesso ao documento, bem como quaisquer dados necessários ao acesso, no campo abaixo.
Todas as denúncias são sigilosas e sua identidade será preservada. Os campos nome e e-mail são de preenchimento opcional. Porém, ao deixar de informar seu e-mail, um possível retorno será inviabilizado e/ou sua denúncia poderá ser desconsiderada no caso de necessitar de informações complementares.
| Metadados | Descrição | Idioma |
|---|---|---|
| Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
| Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
| Autor(es): dc.creator | Diniz, Susana Nogueira | - |
| Autor(es): dc.creator | Passeti, Tânia Aguiar | - |
| Autor(es): dc.creator | de Souza Marquez, Audrey | - |
| Autor(es): dc.creator | Prado, Everton Tadeu | - |
| Autor(es): dc.creator | da Silva, Claudia Forlin | - |
| Autor(es): dc.creator | dos Santos Baeta, Danielli | - |
| Autor(es): dc.creator | Sivieri, Katia | - |
| Data de aceite: dc.date.accessioned | 2025-08-21T19:17:38Z | - |
| Data de disponibilização: dc.date.available | 2025-08-21T19:17:38Z | - |
| Data de envio: dc.date.issued | 2022-04-28 | - |
| Data de envio: dc.date.issued | 2022-04-28 | - |
| Data de envio: dc.date.issued | 2021-04-08 | - |
| Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/222792 | - |
| Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/222792 | - |
| Descrição: dc.description | Methicillin-Resistant Staphylococcus aureus (MRSA) became a major public health concern worldwide. The increase in the prevalence of antibiotic resistant pathogens, the limited efficacy and the adverse events associated with antibiotics have urged the development of complementary and alternative methods to treat Staphylococcus aureus (S. aureus) infections. This chapter provides a compact overview of the feasibility and clinical impact of novel therapies, with a focus on monoclonal antibodies (mAbs), vaccines, bacteriophages, liposomes and nanotechnology, photodynamic therapy (PDT), homeopathy and botanical medicine. Clinical trials with mAbs carried out in subjects with staphylococcal infections demonstrated that the majority failed to prove the efficacy and only a few remain in clinical development. Vaccines targeting S. aureus have recently been tested in clinical trials and although the results seem promising, there is currently no vaccine which has proven to be clinically effective. Several case studies have demonstrated the use of bacteriophages to treat infections caused by S. aureus. Although this kind of treatment demonstrated to be safe and effective, trials involving a larger population are necessary prior to confidently implement bacteriophages into clinical use. The potential use of liposomal compounds for the treatment of staphylococcal infections and to encapsulate antimicrobial agents as delivery methods, has recently emerged. Results showed that the application of liposomes improves the stability of antimicrobial agents and extends the length of activity, being a promising formulation for bacteria targeted delivery and immune system defense. Antibacterial PDT is a new non-antibiotic treatment strategy for a variety of drug-resistant bacteria including MRSA. Findings on recent studies suggest that PDT can effectively inhibit MRSA by damaging cell membrane, cytoplasm, proteins and nucleic acid. The study of plant extracts with antimicrobial activity allows the identification of active molecules and their mechanism of action, which increases the likelihood of new antimicrobial drugs development or their use in association with known antibiotics to enhance antimicrobial activity. Finally, homeopathic treatment may improve the clinical condition of patients, reduce the need for conventional antimicrobial agents and decrease the relapse rate of infection. Promising results have been obtained with the use of Belladona and MRSA isotherapic to inhibit MRSA growth in vitro, suggesting that this phenomenon was not due to bacterial cell death, but rather to a marked decrease in its growth rate, which probably make the bacteria more sensitive to oxacillin. As discussed in this chapter, there are several promising new complementary and alternative therapeutics towards MRSA that may be successfully used in combination with the available conventional antibimicrobial treatments. | - |
| Descrição: dc.description | Department of Pharmacy and Biotechonology and Health Innovation Anhanguera University of São Paulo | - |
| Descrição: dc.description | Center of Research in Health Sciences Unopar University Anhanguera University of São Paulo | - |
| Descrição: dc.description | School of Pharmaceutical Sciences São Paulo State University | - |
| Descrição: dc.description | Department of Biotechonology and Health Innovation Anhanguera University of São Paulo São Paulo State University | - |
| Descrição: dc.description | School of Pharmaceutical Sciences São Paulo State University | - |
| Descrição: dc.description | Department of Biotechonology and Health Innovation Anhanguera University of São Paulo São Paulo State University | - |
| Formato: dc.format | 703-751 | - |
| Idioma: dc.language | en | - |
| Relação: dc.relation | The Encyclopedia of Bacteriology Research Developments | - |
| ???dc.source???: dc.source | Scopus | - |
| Palavras-chave: dc.subject | Bacteriophages | - |
| Palavras-chave: dc.subject | Botanical medicine | - |
| Palavras-chave: dc.subject | Complementary and alternative therapies | - |
| Palavras-chave: dc.subject | Homeopathy | - |
| Palavras-chave: dc.subject | Liposomes | - |
| Palavras-chave: dc.subject | Methicillin-resistant Staphylococcus aureus (MRSA) | - |
| Palavras-chave: dc.subject | Monoclonal antibodies (mAbs) | - |
| Palavras-chave: dc.subject | Nanotechnology | - |
| Palavras-chave: dc.subject | Photodynamic therapy (PDT) | - |
| Palavras-chave: dc.subject | Vaccines | - |
| Título: dc.title | New complementary and alternative therapies to control methicillin-resistant staphylococcus aureus (MRSA) infection | - |
| Tipo de arquivo: dc.type | livro digital | - |
| Aparece nas coleções: | Repositório Institucional - Unesp | |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: