Antiglycation and antitumoral activity of Tribulus terrestris dry extract

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorFundação Educacional do Município de Assis (FEMA)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorFigueiredo, Célia Cristina Malaguti-
Autor(es): dc.creatorGomes, Amanda Costa-
Autor(es): dc.creatorGranero, Filipe Oliveira-
Autor(es): dc.creatorJunior, João Luiz Bronzel-
Autor(es): dc.creatorSilva, Luciana Pereira-
Autor(es): dc.creatorRuiz, Ana Lúcia Tasca Gois-
Autor(es): dc.creatorda Silva, Regildo Márcio Gonçalves-
Data de aceite: dc.date.accessioned2025-08-21T17:02:05Z-
Data de disponibilização: dc.date.available2025-08-21T17:02:05Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-05-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.22038/AJP.2020.16957-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222791-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222791-
Descrição: dc.descriptionObjective: Investigation of the antiglycation and antitumoral potential of standardized and saponins-enriched extracts of Tribulus terrestris herbal medicine. Materials and Methods: The procedures for the evaluation of the antiglycation activity of the standardized (TtSE) and saponins-enriched (TtEE) extracts of T. terrestris were: determination of relative mobility in electrophoresis (RME), free amino groups using OPA method and advanced glycation end-products (AGEs) fluorescence. Antioxidant activity was determined by DPPH radical scavenging test. In vitro antitumor activity of TtSE and TtEE was evaluated in human tumor cell lines. Results: The results were obtained by antiglycation tests (RME, OPA method and AGEs fluorescence determination), using BSA as protein and ribose as glycation agent, and antioxidant assay (DPPH test); it was verified that both extracts of T. terrestris have antiglycation and antioxidant activity. In addition, the extracts were able to induce death of more than 50% of human tumor cell lines. Conclusion: The present study showed that standardized and saponins-enriched extracts of T. terrestris herbal medicine present antiglycation and antioxidant and antiproliferative action in human tumor cells lines. The saponins-enriched extract proved a greater antiglycation and antioxidant activity in comparison to the standardized type.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionFundação Educacional do Município de Assis (FEMA)-
Descrição: dc.descriptionUniversity of Campinas (UNICAMP) Faculty of Pharmaceutical Sciences-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences Humanities and Languages Department of Biotechnology Laboratory of Herbal Medicine and Natural Products-
Descrição: dc.descriptionSão Paulo State University (UNESP) Institute of Chemistry-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Sciences Humanities and Languages Department of Biotechnology Laboratory of Herbal Medicine and Natural Products-
Descrição: dc.descriptionFAPESP: 2015/17893-3-
Formato: dc.format224-237-
Idioma: dc.languageen-
Relação: dc.relationAvicenna Journal of Phytomedicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntiproliferative-
Palavras-chave: dc.subjectProtein glycation-
Palavras-chave: dc.subjectSteroidal saponins-
Palavras-chave: dc.subjectTribulus terrestris-
Título: dc.titleAntiglycation and antitumoral activity of Tribulus terrestris dry extract-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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