Topical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing

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Autor(es): dc.contributorUniversidade de Franca-
Autor(es): dc.contributorInstituto Federal do Sul de Minas Gerais-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorDias, Fernanda Gosuen Gonçalves-
Autor(es): dc.creatorde Freitas Pereira, Lucas-
Autor(es): dc.creatorFurtado, Ricardo Andrade-
Autor(es): dc.creatorMagalhães, Geórgia Modé-
Autor(es): dc.creatorMiguel, Marina Pacheco-
Autor(es): dc.creatorDias, Luis Gustavo Gosuen Gonçalves-
Autor(es): dc.creatorJorge, Adriana Torrecilhas-
Autor(es): dc.creatordos Santos Honsho, Cristiane-
Autor(es): dc.creatorAmbrósio, Sérgio Ricardo-
Autor(es): dc.creatorBastos, Jairo Kenupp-
Autor(es): dc.creatorCarrijo, Micaela Silva-
Autor(es): dc.creatorTavares, Denise Crispim-
Data de aceite: dc.date.accessioned2025-08-21T17:47:04Z-
Data de disponibilização: dc.date.available2025-08-21T17:47:04Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-03-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.22038/AJP.2020.16821-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222790-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222790-
Descrição: dc.descriptionObjective: Evaluation of the healing and toxicological effects of Copaifera duckei Dwyer oleoresin (CDO). Materials and Methods: Rodents with skin lesions were divided into nine groups, including daily treatments with 1, 3 and 10% CDO, collagenase, antibiotic ointment and control groups, for 14 days. Results: Treatment with 10% CDO reduced skin edema and hyperplasia, demonstrating anti-inflammatory effect of the oil. Reduction in the wound area was observed, indicating the healing effect of CDO. Histopathological analysis showed increases in angiogenesis and re-epithelialization in animals treated with the highest concentration. On the other hand, no alterations in ulcerations, inflammatory infiltrate, hemorrhage, congestion, degeneration, percentage of collagen fibers, number of cells stained with anti-macrophage migration inhibitory factor, or density of area stained with anti-collagen I and III were found. Toxicogenetic analysis revealed no differences in micronucleus frequencies or in the ratio of polychromatic erythrocytes to total erythrocytes between treated and negative control, demonstrating the absence of genotoxicity and cytotoxicity, respectively. There was no difference in levels of liver enzymes among groups, indicating the absence of hepatotoxicity. Conclusion: Formulations of CDO exerted beneficial effects on the stages of cutaneous wound healing and are promising options for the treatment of wounds.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Veterinary Medicine Universidade de Franca-
Descrição: dc.descriptionDepartment of Veterinary Medicine Instituto Federal do Sul de Minas Gerais-
Descrição: dc.descriptionDepartment of Veterinary Medicine Universidade Federal de Goiás-
Descrição: dc.descriptionDepartment of Veterinary Medicine Universidade Estadual Paulista-
Descrição: dc.descriptionDepartment of Sciences Universidade de Franca-
Descrição: dc.descriptionDepartment of Pharmacy Universidade de São Paulo-
Descrição: dc.descriptionDepartment of Veterinary Medicine Universidade Estadual Paulista-
Descrição: dc.descriptionFAPESP: 2011/13630-7-
Formato: dc.format120-133-
Idioma: dc.languageen-
Relação: dc.relationAvicenna Journal of Phytomedicine-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCopaifera duckei Dwyer oleoresin-
Palavras-chave: dc.subjectCutaneous wound healing-
Palavras-chave: dc.subjectToxicity-
Título: dc.titleTopical formulations containing Copaifera duckei Dwyer oleoresin improve cutaneous wound healing-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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