Efficacy and safety of repellents marketed in Brazil against bites from Aedes aegypti and Aedes albopictus: A systematic review

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorGraduate Program in Pharmaceutical Sciences-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorGomes Fernandes, Maria Raquel-
Autor(es): dc.creatorCruz Lopes, Luciane-
Autor(es): dc.creatorSuguimoto Iwami, Rodrigo-
Autor(es): dc.creatorDel Grossi Paglia, Mariana-
Autor(es): dc.creatorMateus de Castilho, Bruna-
Autor(es): dc.creatorMaicon de Oliveira, Alan-
Autor(es): dc.creatorFulone, Izabela-
Autor(es): dc.creatorSilveira Leite, Ricardo-
Autor(es): dc.creatorde Cássia Bergamaschi, Cristiane-
Data de aceite: dc.date.accessioned2025-08-21T16:12:22Z-
Data de disponibilização: dc.date.available2025-08-21T16:12:22Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.tmaid.2021.102179-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222751-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222751-
Descrição: dc.descriptionBackground: Dengue, Zika and Chikungunya viruses represent a serious public health problem. No evidence is available on the efficacy of repellents commercially available in Brazil. This systematic review assessed the efficacy and safety of products containing repellents commercially available in Brazil for protection against bites from Aedes aegypti and Aedes albopictus. Methods: We performed a systematic review using the CENTRAL, MEDLINE, EMBASE, CINAHL, Web of Science, AMED, LILACS and Scopus databases. Randomized clinical trials and non-randomized clinical trials comparing topical repellent products registered with the Brazilian Health Surveillance Agency were included. Main outcomes of interest investigated were adverse effects, percentage repellency and protection time against bites. Pairs of reviewers selected the studies, extracted the data and evaluated the risk of bias. Results: Sixteen studies were included. No adverse effects were reported by the studies. Against Ae. aegypti: protection time using DEET (10% and 20%-spray) was similar to IR3535 (10% and 20%-spray) and longer than citronella (5%-spray). DEET (25%-solution) had longer protection time than eucalyptus (25%-solution), while DEET (20%-lotion) had longer protection time than citronella (10%-lotion). There was no difference in protection time between herbal repellents. DEET (7% and 15%- spray) had higher percentage repellency compared to both icaridin (7%-spray) and IR3535 (20%-spray). Against Ae. albopictus: DEET (15%-spray) had a similar protection time to icaridin (20%-spray), but longer than citronella (10%-spray). Conclusion: DEET proved more effective than the other synthetic and natural repellents marketed in Brazil for protecting against bites from the mosquito species investigated. All repellents studied exhibited satisfactory safety profile.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Agricultural Sciences Department of Bioprocesses and Biotechnology Multiuser Central Laboratory-
Descrição: dc.descriptionUniversity of Sorocaba (UNISO) Graduate Program in Pharmaceutical Sciences-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Science Department of Clinical Analysis-
Descrição: dc.descriptionUniversity of São Paulo (USP) School of Pharmaceutical Sciences of Ribeirão Preto Department of Pharmaceutical Sciences-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Agricultural Sciences Department of Bioprocesses and Biotechnology Multiuser Central Laboratory-
Descrição: dc.descriptionSão Paulo State University (UNESP) School of Pharmaceutical Science Department of Clinical Analysis-
Descrição: dc.descriptionFAPESP: 2017/07813-8-
Descrição: dc.descriptionFAPESP: 2017/07813–8-
Idioma: dc.languageen-
Relação: dc.relationTravel Medicine and Infectious Disease-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChikungunya-
Palavras-chave: dc.subjectDengue-
Palavras-chave: dc.subjectEfficacy-
Palavras-chave: dc.subjectInsect repellents-
Palavras-chave: dc.subjectSafety-
Palavras-chave: dc.subjectZika-
Título: dc.titleEfficacy and safety of repellents marketed in Brazil against bites from Aedes aegypti and Aedes albopictus: A systematic review-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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