Zebrafish as a model to study inflammation: A tool for drug discovery

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorBrazil University (UB)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorFederal University of Roraima-
Autor(es): dc.contributorButantan Institute-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorBelo, Marco A.A.-
Autor(es): dc.creatorOliveira, Melque F.-
Autor(es): dc.creatorOliveira, Susana L.-
Autor(es): dc.creatorAracati, Mayumi F.-
Autor(es): dc.creatorRodrigues, Letícia F.-
Autor(es): dc.creatorCosta, Camila C.-
Autor(es): dc.creatorConde, Gabriel-
Autor(es): dc.creatorGomes, Juliana M.M.-
Autor(es): dc.creatorPrata, Mariana N.L.-
Autor(es): dc.creatorBarra, Ayslan-
Autor(es): dc.creatorValverde, Thalita M.-
Autor(es): dc.creatorde Melo, Daniela C.-
Autor(es): dc.creatorEto, Silas F.-
Autor(es): dc.creatorFernandes, Dayanne C.-
Autor(es): dc.creatorRomero, Marina G.M.C.-
Autor(es): dc.creatorCorrêa Júnior, José D.-
Autor(es): dc.creatorSilva, Juliana O.-
Autor(es): dc.creatorBarros, Andre L.B.-
Autor(es): dc.creatorPerez, Andrea C.-
Autor(es): dc.creatorCharlie-Silva, Ives-
Data de aceite: dc.date.accessioned2025-08-21T18:01:36Z-
Data de disponibilização: dc.date.available2025-08-21T18:01:36Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.biopha.2021.112310-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222651-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222651-
Descrição: dc.descriptionThis study aims to demonstrate the applicability and importance of zebrafish (Danio rerio) model to study acute and chronic inflammatory responses induced by different stimuli: carrageenan phlogogen (nonimmune); acute infection by bacteria (immune); foreign body reaction (chronic inflammation by round glass coverslip implantation); reaction induced by xenotransplantation. In addition to the advantages of presenting low breeding cost, high prolificity, transparent embryos, high number of individuals belonging to the same spawning and high genetic similarity that favor translational responses to vertebrate organisms like humans, zebrafish proved to be an excellent tool, allowing the evaluation of edema formation, accumulation of inflammatory cells in the exudate, mediators, signaling pathways, gene expression and production of specific proteins. Our studies demonstrated the versatility of fish models to investigate the inflammatory response and its pathophysiology, essential for the successful development of studies to discover innovative pharmacological strategies.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratory of Animal Pharmacology and Toxicology Brazil University (UB)-
Descrição: dc.descriptionDepartment of Preventive Veterinary Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Morphology Federal University of Minas Gerais (UFMG)-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology Federal University of Minas Gerais (UFMG)-
Descrição: dc.descriptionDepartment of Biochemistry and Immunology Federal University of Minas Gerais (UFMG)-
Descrição: dc.descriptionDepartment of zootechnics at the Veterinary School Federal University of Minas Gerais (UFMG)-
Descrição: dc.descriptionPostgraduate Program in Health Sciences - PROCISA Federal University of Roraima-
Descrição: dc.descriptionImmunochemistry Laboratory Butantan Institute-
Descrição: dc.descriptionDepartment of Clinical and Toxicological Analyses Federal University of Minas Gerais (UFMG)-
Descrição: dc.descriptionDepartment of Pharmacology University of São Paulo (ICB-USP)-
Descrição: dc.descriptionDepartment of Preventive Veterinary Medicine São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2013/25971-9-
Descrição: dc.descriptionFAPESP: 2018/07098-0-
Descrição: dc.descriptionFAPESP: 2019/19939-1-
Descrição: dc.descriptionCNPq: 301473 / 2016-1-
Descrição: dc.descriptionCNPq: 307526/2018-6-
Descrição: dc.descriptionCNPq: 477816/2013-4-
Idioma: dc.languageen-
Relação: dc.relationBiomedicine and Pharmacotherapy-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcute and chronic inflammation-
Palavras-chave: dc.subjectForeign body reaction-
Palavras-chave: dc.subjectInflammatory reaction-
Palavras-chave: dc.subjectInnate Immunity-
Palavras-chave: dc.subjectTeleost fish-
Palavras-chave: dc.subjectXenotransplantation-
Título: dc.titleZebrafish as a model to study inflammation: A tool for drug discovery-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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