Luminescence and cytotoxic study of red emissive europium(III) complex as a cell dye

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCanisares, Felipe S.M.-
Autor(es): dc.creatorMutti, Alessandra M.G.-
Autor(es): dc.creatorCavalcante, Dalita G.S.M.-
Autor(es): dc.creatorJob, Aldo E.-
Autor(es): dc.creatorPires, Ana M.-
Autor(es): dc.creatorLima, Sergio A.M.-
Data de aceite: dc.date.accessioned2025-08-21T21:48:36Z-
Data de disponibilização: dc.date.available2025-08-21T21:48:36Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.jphotochem.2021.113552-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222620-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222620-
Descrição: dc.descriptionA novel non-toxic red luminescent Eu(III)-complex, (Na[Eu(Fmpc)4(H2O)4]∙3H2O), based on a carboxylic acid ligand was synthesized and characterized by several techniques, such as elemental analysis, MALDI TOF spectrometry, thermogravimetric analyses, UV–vis, FT-IR, and photoluminescence spectroscopies; also its structure was optimized theoretically by the AM1 sparkle model. The Gd(III)-complex, (Na[Gd(Fmpc)4(H2O)3]∙4H2O), was also synthesized and characterized, to evaluate the Fmpc ligand triplet excited state, revealing that the energy of the ligand is suitable to sensitize the similar Eu(III)-complex, indicating a high sensitization rate of the Fmpc ligand to Eu3+ ion with 98% efficiency. The Na[Eu(Fmpc)4(H2O)4]∙3H2O luminescent properties were investigated, and its excited state lifetime was also determined as 0.76 ms in acetonitrile solution. The complex relative quantum yield was estimated to be 27.9%, evidencing that the Fmpc ligand is efficient in transferring the absorbed energy to the europium(III) ion emitting level. Furthermore, the cytotoxicity of Na[Eu(Fmpc)4(H2O)4]∙3H2O was tested in CHO-k1 cells by the MTT assay, and no cytotoxicity was observed at 24 h of exposure within the concentrations tested (25–200 µg/mL). Its use for cell imaging was also evaluated by fluorescence and confocal microscopies. Our findings indicated that Na[Eu(Fmpc)4(H2O)4]∙3H2O complex exhibited great luminescent properties, it is non-toxic, and it has potential for bioimaging application as a luminescent dye.-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Technology and Sciences-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Chemistry-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Biosciences Humanities and Exact Sciences-
Descrição: dc.descriptionSão Paulo State University (Unesp) School of Technology and Sciences-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Chemistry-
Descrição: dc.descriptionSão Paulo State University (Unesp) Institute of Biosciences Humanities and Exact Sciences-
Idioma: dc.languageen-
Relação: dc.relationJournal of Photochemistry and Photobiology A: Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCell imaging-
Palavras-chave: dc.subjectConfocal microscopy-
Palavras-chave: dc.subjectLanthanides-
Palavras-chave: dc.subjectNon-toxic-
Palavras-chave: dc.subjectRare earth-
Palavras-chave: dc.subjectRed emitter-
Título: dc.titleLuminescence and cytotoxic study of red emissive europium(III) complex as a cell dye-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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