A simple spectrophotometric method for the determination of captopril in pharmaceutical preparations using ammonium molybdate

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorSaúde e Tecnologia - UFMA-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorRibeiro, P. R.S.-
Autor(es): dc.creatorPezza, L.-
Autor(es): dc.creatorPezza, H. R.-
Data de aceite: dc.date.accessioned2025-08-21T15:25:34Z-
Data de disponibilização: dc.date.available2025-08-21T15:25:34Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2010-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.26850/1678-4618EQJ.V35.3.2010.P179-188-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222608-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222608-
Descrição: dc.descriptionA simple, rapid and sensitive spectrophotometric method for the determination of captopril (CPT) in pharmaceutical formulations is proposed. This method is based on the reduction reaction of ammonium molybdate, in the presence of sulphuric acid, for the group thiol of CPT, producing a green compound (λmax407 nm). Beer's law is obeyed in a concentration range of 4.60 x 10-4- 1.84 x 10-3mol l-1of CPT with an excellent correlation coefficient (r = 0.9995). The limit of detection and limit of quantification were 7.31 x 10-6e 2.43 x 10-5mol l-1of CPT, respectively. The proposed method was successfully applied to the determination of CPT in commercial brands of pharmaceuticals. No interferences were observed from the common excipients in the formulations. The results obtained by the proposed method were favorably compared with those given by the official reported method at 95 % confidence level.-
Descrição: dc.descriptionCentro de Ciências Sociais Saúde e Tecnologia - UFMA, MA-
Descrição: dc.descriptionInstituto de Química - UNESP, P.O. Box 355, SP-
Descrição: dc.descriptionInstituto de Química - UNESP, P.O. Box 355, SP-
Formato: dc.format179-188-
Idioma: dc.languageen-
Relação: dc.relationEcletica Quimica-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAmmonium Molybdate-
Palavras-chave: dc.subjectCaptopril-
Palavras-chave: dc.subjectSpectrophotometric determination-
Título: dc.titleA simple spectrophotometric method for the determination of captopril in pharmaceutical preparations using ammonium molybdate-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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