Drosophila melanogaster: A Powerful Tiny Animal Model for the Study of Metabolic Hepatic Diseases

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversité Paris-Saclay-
Autor(es): dc.creatorMoraes, Karen C. M.-
Autor(es): dc.creatorMontagne, Jacques-
Data de aceite: dc.date.accessioned2025-08-21T22:24:52Z-
Data de disponibilização: dc.date.available2025-08-21T22:24:52Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-09-16-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fphys.2021.728407-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222564-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222564-
Descrição: dc.descriptionAnimal experimentation is limited by unethical procedures, time-consuming protocols, and high cost. Thus, the development of innovative approaches for disease treatment based on alternative models in a fast, safe, and economic manner is an important, yet challenging goal. In this paradigm, the fruit-fly Drosophila melanogaster has become a powerful model for biomedical research, considering its short life cycle and low-cost maintenance. In addition, biological processes are conserved and homologs of ∼75% of human disease-related genes are found in the fruit-fly. Therefore, this model has been used in innovative approaches to evaluate and validate the functional activities of candidate molecules identified via in vitro large-scale analyses, as putative agents to treat or reverse pathological conditions. In this context, Drosophila offers a powerful alternative to investigate the molecular aspects of liver diseases, since no effective therapies are available for those pathologies. Non-alcoholic fatty liver disease is the most common form of chronic hepatic dysfunctions, which may progress to the development of chronic hepatitis and ultimately to cirrhosis, thereby increasing the risk for hepatocellular carcinoma (HCC). This deleterious situation reinforces the use of the Drosophila model to accelerate functional research aimed at deciphering the mechanisms that sustain the disease. In this short review, we illustrate the relevance of using the fruit-fly to address aspects of liver pathologies to contribute to the biomedical area.-
Descrição: dc.descriptionCentre National de la Recherche Scientifique-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionInstitut National de Physique Nucléaire et de Physique des Particules-
Descrição: dc.descriptionInstitut de chimie-
Descrição: dc.descriptionInstitut écologie et environnement-
Descrição: dc.descriptionInstitut de physique-
Descrição: dc.descriptionInstitut des sciences de l'information et de leurs interactions-
Descrição: dc.descriptionInstitut des sciences biologiques-
Descrição: dc.descriptionInstitut des sciences humaines et sociales-
Descrição: dc.descriptionInstitut des sciences de l'ingénierie et des systèmes-
Descrição: dc.descriptionInstitut national des sciences mathématiques et de leurs interactions-
Descrição: dc.descriptionInstitut national des sciences de l'Univers-
Descrição: dc.descriptionLaboratório de Sinalização Celular e Expressão Gênica Departamento de Biologia Geral e Aplicada Instituto de Biociências UNESP-
Descrição: dc.descriptionInstitute for Integrative Biology of the Cell (I2BC) CEA CNRS Université Paris-Saclay-
Descrição: dc.descriptionLaboratório de Sinalização Celular e Expressão Gênica Departamento de Biologia Geral e Aplicada Instituto de Biociências UNESP-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Physiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectalternative animal model-
Palavras-chave: dc.subjectDrosophila-
Palavras-chave: dc.subjectgenetics-
Palavras-chave: dc.subjectliver diseases-
Palavras-chave: dc.subjectsystem biology-
Título: dc.titleDrosophila melanogaster: A Powerful Tiny Animal Model for the Study of Metabolic Hepatic Diseases-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

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