The interplay between 5-HT2C and 5-HT3A receptors in the dorsal periaqueductal gray mediates anxiety-like behavior in mice

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Autor(es): dc.contributorUniversidade Federal de São Carlos (UFSCar)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorNeuroscience and Behavioral Institute-
Autor(es): dc.contributorThe University of Calgary-
Autor(es): dc.contributorSchool of Behavior and Brain Sciences-
Autor(es): dc.contributorTexas Biomedical Device Center-
Autor(es): dc.creatorLopes, Luana Tenorio-
Autor(es): dc.creatorCanto-de-Souza, Lucas-
Autor(es): dc.creatorBaptista-de-Souza, Daniela-
Autor(es): dc.creatorde Souza, Rimenez Rodrigues-
Autor(es): dc.creatorNunes-de-Souza, Ricardo L.-
Autor(es): dc.creatorCanto-de-Souza, Azair-
Data de aceite: dc.date.accessioned2025-08-21T16:31:48Z-
Data de disponibilização: dc.date.available2025-08-21T16:31:48Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-01-23-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2021.113588-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222478-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222478-
Descrição: dc.descriptionThe monoamine neurotransmitter serotonin (5-HT) modulates anxiety by its activity on 5-HT2C receptors (5-HT2CR) expressed in the dorsal periaqueductal gray (dPAG). Here, we investigated the presence of 5-HT3A receptors (5-HT3AR) in the dPAG, and the interplay between 5-HT2CR and 5-HT3AR in the dPAG in mediating anxiety-like behavior in mice. We found that 5-HT3AR is expressed in the dPAG and the blockade of these receptors using intra-dPAG infusion of ondansetron (5-HT3AR antagonist; 3.0 nmol) induced an anxiogenic-like effect. The activation of 5-HT3ABR by the infusion of mCPBG [1-(m-Chlorophenyl)-biguanide; 5-HT3R agonist] did not alter anxiety-like behaviors. In addition, blockade of 5-HT3AR (1.0 nmol) prevented the anxiolytic-like effect induced by the infusion of the 5-HT2CR agonist mCPP (1-(3-chlorophenyl) piperazine; 0.03 nmol). None of the treatment effects on anxiety-like behaviors altered the locomotor activity levels. The present results suggest that the anxiolytic-like effect exerted by serotonin activity on 5-HT2CR in the dPAG is modulated by 5-HT3AR expressed in same region.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionPsychobiology Group/Department of Psychology/CECH–UFSCar-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences UFSCar/UNESP, Rod. Washington Luís, Km 235-
Descrição: dc.descriptionGraduate Program in Psychology UFSCar, Rod. Washington Luís, Km 235-
Descrição: dc.descriptionLaboratory of Pharmacology School of Pharmaceutical Sciences Univ. Estadual Paulista UNESP-
Descrição: dc.descriptionNeuroscience and Behavioral Institute, Av. do Café, 2.450-
Descrição: dc.descriptionDepartment of Physiology and Pharmacology Hotchkiss Brain Institute The University of Calgary-
Descrição: dc.descriptionThe University of Texas at Dallas School of Behavior and Brain Sciences, 800 West Campbell Road-
Descrição: dc.descriptionThe University of Texas at Dallas Texas Biomedical Device Center, 800 West Campbell Road-
Descrição: dc.descriptionJoint Graduate Program in Physiological Sciences UFSCar/UNESP, Rod. Washington Luís, Km 235-
Descrição: dc.descriptionLaboratory of Pharmacology School of Pharmaceutical Sciences Univ. Estadual Paulista UNESP-
Descrição: dc.descriptionFAPESP: 2016/08665-0-
Descrição: dc.descriptionCNPq: 88887.194785/2018-00-
Idioma: dc.languageen-
Relação: dc.relationBehavioural Brain Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subject5-HT3A and 5-HT2C receptors-
Palavras-chave: dc.subjectElevated Plus-Maze (EPM)-
Palavras-chave: dc.subjectMCPBG-
Palavras-chave: dc.subjectMCPP-
Palavras-chave: dc.subjectMice-
Palavras-chave: dc.subjectOndansetron-
Título: dc.titleThe interplay between 5-HT2C and 5-HT3A receptors in the dorsal periaqueductal gray mediates anxiety-like behavior in mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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