Late-in-life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts

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Autor(es): dc.contributorUniversity of Utah-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCho, Jae Min-
Autor(es): dc.creatorPark, Seul-Ki-
Autor(es): dc.creatorGhosh, Rajeshwary-
Autor(es): dc.creatorLy, Kellsey-
Autor(es): dc.creatorRamous, Caroline-
Autor(es): dc.creatorThompson, Lauren-
Autor(es): dc.creatorHansen, Michele-
Autor(es): dc.creatorMattera, Maria Sara de Lima Coutinho-
Autor(es): dc.creatorPires, Karla Maria-
Autor(es): dc.creatorFerhat, Maroua-
Autor(es): dc.creatorMookherjee, Sohom-
Autor(es): dc.creatorWhitehead, Kevin J.-
Autor(es): dc.creatorCarter, Kandis-
Autor(es): dc.creatorBuffolo, Márcio-
Autor(es): dc.creatorBoudina, Sihem-
Autor(es): dc.creatorSymons, J. David-
Data de aceite: dc.date.accessioned2025-08-21T15:48:21Z-
Data de disponibilização: dc.date.available2025-08-21T15:48:21Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2020-12-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/acel.13467-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222457-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222457-
Descrição: dc.descriptionProtein quality control mechanisms decline during the process of cardiac aging. This enables the accumulation of protein aggregates and damaged organelles that contribute to age-associated cardiac dysfunction. Macroautophagy is the process by which post-mitotic cells such as cardiomyocytes clear defective proteins and organelles. We hypothesized that late-in-life exercise training improves autophagy, protein aggregate clearance, and function that is otherwise dysregulated in hearts from old vs. adult mice. As expected, 24-month-old male C57BL/6J mice (old) exhibited repressed autophagosome formation and protein aggregate accumulation in the heart, systolic and diastolic dysfunction, and reduced exercise capacity vs. 8-month-old (adult) mice (all p < 0.05). To investigate the influence of late-in-life exercise training, additional cohorts of 21-month-old mice did (old-ETR) or did not (old-SED) complete a 3-month progressive resistance treadmill running program. Body composition, exercise capacity, and soleus muscle citrate synthase activity improved in old-ETR vs. old-SED mice at 24 months (all p < 0.05). Importantly, protein expression of autophagy markers indicate trafficking of the autophagosome to the lysosome increased, protein aggregate clearance improved, and overall function was enhanced (all p < 0.05) in hearts from old-ETR vs. old-SED mice. These data provide the first evidence that a physiological intervention initiated late-in-life improves autophagic flux, protein aggregate clearance, and contractile performance in mouse hearts.-
Descrição: dc.descriptionNutrition and Integrative Physiology University of Utah-
Descrição: dc.descriptionSchool of Dentistry Sao Paulo State University-
Descrição: dc.descriptionMolecular Medicine Program University of Utah-
Descrição: dc.descriptionDivision of Cardiovascular Medicine and Pediatric Cardiology University of Utah-
Descrição: dc.descriptionGeorge E Wahlen VA Medical Center University of Utah-
Descrição: dc.descriptionSchool of Dentistry Sao Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationAging Cell-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectaging-
Palavras-chave: dc.subjectcardiac function-
Palavras-chave: dc.subjectexercise-
Palavras-chave: dc.subjectprotein aggregates-
Título: dc.titleLate-in-life treadmill training rejuvenates autophagy, protein aggregate clearance, and function in mouse hearts-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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