Actions and roles of fsh in germinative cells

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Guelph-
Autor(es): dc.creatorRecchia, Kaiana-
Autor(es): dc.creatorJorge, Amanda Soares-
Autor(es): dc.creatorPessôa, Laís Vicari de Figueiredo-
Autor(es): dc.creatorBotigelli, Ramon Cesar-
Autor(es): dc.creatorZugaib, Vanessa Cristiane-
Autor(es): dc.creatorde Souza, Aline Fernanda-
Autor(es): dc.creatorMartins, Daniele Dos Santos-
Autor(es): dc.creatorAmbrósio, Carlos Eduardo-
Autor(es): dc.creatorBressan, Fabiana Fernandes-
Autor(es): dc.creatorPieri, Naira Caroline Godoy-
Data de aceite: dc.date.accessioned2025-08-21T22:35:05Z-
Data de disponibilização: dc.date.available2025-08-21T22:35:05Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-09-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3390/ijms221810110-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222431-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222431-
Descrição: dc.descriptionFollicle stimulating hormone (FSH) is produced by the pituitary gland in a coordinated hypothalamic–pituitary–gonadal (HPG) axis event, plays important roles in reproduction and germ cell development during different phases of reproductive development (fetal, neonatal, puberty, and adult life), and is consequently essential for fertility. FSH is a heterodimeric glycoprotein hormone of two dissociable subunits, α and β. The FSH β-subunit (FSHβ) function starts upon cou-pling to its specific receptor: follicle-stimulating hormone receptor (FSHR). FSHRs are localized mainly on the surface of target cells on the testis and ovary (granulosa and Sertoli cells) and have recently been found in testicular stem cells and extra-gonadal tissue. Several reproduction disorders are associated with absent or low FSH secretion, with mutation of the FSH β-subunit or the FSH receptor, and/or its signaling pathways. However, the influence of FSH on germ cells is still poorly understood; some studies have suggested that this hormone also plays a determinant role in the self-renewal of germinative cells and acts to increase undifferentiated spermatogonia proliferation. In addition, in vitro, together with other factors, it assists the process of differentiation of primordial germ cells (PGCLCs) into gametes (oocyte-like and SSCLCs). In this review, we describe relevant research on the influence of FSH on spermatogenesis and folliculogenesis, mainly in the germ cell of humans and other species. The possible roles of FSH in germ cell generation in vitro are also presented.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Surgery Faculty of Veterinary Medicine and Animal Sciences University of São Paulo-
Descrição: dc.descriptionDepartment of Veterinary Medicine School of Animal Sciences and Food Engineering University of Sao Paulo-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment Biomedical Science Ontary Veterinary College University of Guelph-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2012/05609-0-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Molecular Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGerm cell line-
Palavras-chave: dc.subjectGonadotrophin-
Palavras-chave: dc.subjectReproduction-
Título: dc.titleActions and roles of fsh in germinative cells-
Tipo de arquivo: dc.typevídeo-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.