Genomic comparisons and phylogenetic analysis of mastitis-related staphylococci with a focus on adhesion, biofilm, and related regulatory genes

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Guelph-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.creatorPizauro, Lucas José Luduverio [UNESP]-
Autor(es): dc.creatorde Almeida, Camila Chioda [UNESP]-
Autor(es): dc.creatorSilva, Saura Rodrigues [UNESP]-
Autor(es): dc.creatorMacInnes, Janet I.-
Autor(es): dc.creatorKropinski, Andrew M.-
Autor(es): dc.creatorZafalon, Luiz Francisco-
Autor(es): dc.creatorde Avila, Fernando Antônio [UNESP]-
Autor(es): dc.creatorde Mello Varani, Alessandro [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:12:07Z-
Data de disponibilização: dc.date.available2022-08-04T22:12:07Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-11-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1038/s41598-021-96842-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222318-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222318-
Descrição: dc.descriptionMastitis is a common and costly disease on dairy farms, commonly caused by Staphylococcus spp. though the various species are associated with different clinical outcomes. In the current study, we performed genomic analyses to determine the prevalence of adhesion, biofilm, and related regulatory genes in 478 staphylococcal species isolated from clinical and subclinical mastitis cases deposited in public databases. The most prevalent adhesin genes (ebpS, atl, pls, sasH and sasF) were found in both clinical and subclinical isolates. However, the ebpS gene was absent in subclinical isolates of Staphylococcus arlettae, S. succinus, S. sciuri, S. equorun, S. galinarum, and S. saprophyticus. In contrast, the coa, eap, emp, efb, and vWbp genes were present more frequently in clinical (vs. subclincal) mastitis isolates and were highly correlated with the presence of the biofim operon (icaABCD) and its transcriptional regulator, icaR. Co-phylogenetic analyses suggested that many of these adhesins, biofilm, and associated regulatory genes could have been horizontally disseminated between clinical and subclinical isolates. Our results further suggest that several adhesins, biofilm, and related regulatory genes, which have been overlooked in previous studies, may be of use for virulence profiling of mastitis-related Staphylococcus strains or as potential targets for vaccine development.-
Descrição: dc.descriptionDepartment of Technology Sao Paulo State University-
Descrição: dc.descriptionDepartment of Microbiology Sao Paulo State University-
Descrição: dc.descriptionDepartment of Pathobiology Ontario Veterinary College University of Guelph-
Descrição: dc.descriptionBrazilian Agricultural Research Corporation (EMBRAPA) Embrapa Southeast Livestock-
Descrição: dc.descriptionDepartment of Technology Sao Paulo State University-
Descrição: dc.descriptionDepartment of Microbiology Sao Paulo State University-
Idioma: dc.languageen-
Relação: dc.relationScientific Reports-
???dc.source???: dc.sourceScopus-
Título: dc.titleGenomic comparisons and phylogenetic analysis of mastitis-related staphylococci with a focus on adhesion, biofilm, and related regulatory genes-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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