Ecotoxicity of losartan potassium in aquatic organisms of different trophic levels

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Technology - Paraná-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorResearch Institute Pelé Pequeno Príncipe-
Autor(es): dc.contributorFaculdades Pequeno Príncipe-
Autor(es): dc.creatorReque, Regiane-
Autor(es): dc.creatorCarneiro, Rhaissa Dayane-
Autor(es): dc.creatorYamamoto, Flávia Yoshie-
Autor(es): dc.creatorRamsdorf, Wanessa Algarte-
Autor(es): dc.creatorMartins, Lucia Regina-
Autor(es): dc.creatorGuiloski, Izonete Cristina-
Autor(es): dc.creatorde Freitas, Adriane Martins-
Data de aceite: dc.date.accessioned2022-08-04T22:12:00Z-
Data de disponibilização: dc.date.available2022-08-04T22:12:00Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.etap.2021.103727-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222278-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222278-
Descrição: dc.descriptionThe intensive use of the antihypertensive losartan potassium (LOS) has culminated in its high occurrence in aquatic environments. However, insufficient studies had investigated its effects in non-target organisms. In this study, ecotoxicity of LOS was assessed in aquatic organisms from distinct trophic levels (Desmodesmus subspicatus, Daphnia magna, and Astyanax altiparanae). Genotoxicity was assessed by the comet assay in D. magna and A. altiparanae, and biochemical biomarkers for the fish. LOS was more toxic to D. subspicatus (EC50(72h) = 27.93 mg L−1) than D. magna (EC50 = 303.69 mg L−1). Subsequently, this drug showed to induce more DNA damage in D. magna than A. altiparanae, when exposed to 2.5 mg L−1. No significant stress responses were observed by the fish biomarkers, suggesting that higher trophic levels organisms are more tolerant to LOS toxicity. LOS showed relatively low toxic potential for a short period of exposure, but with different patterns of toxicity for the organisms from distinct trophic levels, contributing to further risk assessment of LOS.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionLaboratory of Ecotoxicology Department of Chemistry and Biology Federal University of Technology - Paraná-
Descrição: dc.descriptionInstitute of Biosciences State University of São Paulo-
Descrição: dc.descriptionResearch Institute Pelé Pequeno Príncipe-
Descrição: dc.descriptionFaculdades Pequeno Príncipe-
Descrição: dc.descriptionFAPESP: 2016/15229-1-
Idioma: dc.languageen-
Relação: dc.relationEnvironmental Toxicology and Pharmacology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAntihypertensive drugs-
Palavras-chave: dc.subjectAquatic organisms-
Palavras-chave: dc.subjectBiochemical biomarkers-
Palavras-chave: dc.subjectDistinct trophic levels-
Palavras-chave: dc.subjectGenotoxicity-
Título: dc.titleEcotoxicity of losartan potassium in aquatic organisms of different trophic levels-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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