Atenção: Todas as denúncias são sigilosas e sua identidade será preservada.
Os campos nome e e-mail são de preenchimento opcional
Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
Autor(es): dc.contributor | Dr. Paulo Prata – FACISB | - |
Autor(es): dc.contributor | Barretos Cancer Hospital | - |
Autor(es): dc.contributor | Ciudad Universitaria UNL | - |
Autor(es): dc.contributor | University of Illinois at Urbana-Champaign | - |
Autor(es): dc.creator | de Freitas, Thiago [UNESP] | - |
Autor(es): dc.creator | Zapaterini, Joyce R. [UNESP] | - |
Autor(es): dc.creator | Moreira, Cristiane M. [UNESP] | - |
Autor(es): dc.creator | de Aquino, Ariana M. [UNESP] | - |
Autor(es): dc.creator | Alonso-Costa, Luiz G. [UNESP] | - |
Autor(es): dc.creator | Bidinotto, Lucas T. [UNESP] | - |
Autor(es): dc.creator | Kass, Laura | - |
Autor(es): dc.creator | Flaws, Jodi A. | - |
Autor(es): dc.creator | Scarano, Wellerson R. [UNESP] | - |
Autor(es): dc.creator | Barbisan, Luis F. [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-08-04T22:11:59Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T22:11:59Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2021-10-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1016/j.fct.2021.112519 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/222275 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/222275 | - |
Descrição: dc.description | Phthalates metabolites have been detected in the urine of pregnant and breastfeeding women. Thus, this study evaluated the adverse effects of maternal exposure to a mixture of six phthalates (Pth mix) on the mammary gland development and carcinogenesis in F1 female offspring. Pregnant female Sprague-Dawley rats were exposed daily to vehicle or Pth mix (35.22% diethyl-phthalate, 21.03% di-(2-ethylhexyl)-phthalate, 14.91% dibutyl-phthalate, 15.10% diisononyl-phthalate, 8.61% diisobutyl-phthalate, and 5.13% benzylbutyl-phthalate) by gavage at 20 μg/kg, 200 μg/kg or 200 mg/kg during gestational day 10 (GD 10) to postnatal day 21 (PND 21). After weaning (PND 22), some female offspring were euthanized for mammary gland analyses while other females received a single dose of N-methyl-N-nitrosourea (MNU, 50 mg/kg) or vehicle and then tumor incidence and multiplicity were recorded until PND 180. Maternal Pth mix exposure increased the number of Ki-67 and progesterone receptor-positive epithelial cells in the mammary gland from Pth mix 200 at μg/kg and 200 mg/kg groups. In addition, tumor incidence and mean number were higher only in Pth mix at 200 mg/kg when compared to the vehicle-treated group, and percentage of tumor-free animals was lower in Pth mix at 200 μg/kg and 200 mg/kg groups. The findings indicate that perinatal Pth mixture exposure increased susceptibility to MNU-induced mammary carcinogenesis in adult F1 female offspring. | - |
Descrição: dc.description | Department of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Pathology School of Medicine Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Barretos School of Health Sciences Dr. Paulo Prata – FACISB | - |
Descrição: dc.description | Molecular Oncology Research Center Barretos Cancer Hospital | - |
Descrição: dc.description | Instituto de Salud y Ambiente del Litoral (ISAL UNL-CONICET) Facultad de Bioquímica y Ciencias Biológicas Ciudad Universitaria UNL | - |
Descrição: dc.description | Department of Comparative Biosciences University of Illinois at Urbana-Champaign | - |
Descrição: dc.description | Department of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP) | - |
Descrição: dc.description | Department of Pathology School of Medicine Sao Paulo State University (UNESP) | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Food and Chemical Toxicology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Chemically-induced mammary tumor | - |
Palavras-chave: dc.subject | F1female offspring | - |
Palavras-chave: dc.subject | Mammary gland development and cancer susceptibility | - |
Palavras-chave: dc.subject | Phthalate mixture | - |
Título: dc.title | Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
O Portal eduCAPES é oferecido ao usuário, condicionado à aceitação dos termos, condições e avisos contidos aqui e sem modificações. A CAPES poderá modificar o conteúdo ou formato deste site ou acabar com a sua operação ou suas ferramentas a seu critério único e sem aviso prévio. Ao acessar este portal, você, usuário pessoa física ou jurídica, se declara compreender e aceitar as condições aqui estabelecidas, da seguinte forma: