Prenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorDr. Paulo Prata – FACISB-
Autor(es): dc.contributorBarretos Cancer Hospital-
Autor(es): dc.contributorCiudad Universitaria UNL-
Autor(es): dc.contributorUniversity of Illinois at Urbana-Champaign-
Autor(es): dc.creatorde Freitas, Thiago [UNESP]-
Autor(es): dc.creatorZapaterini, Joyce R. [UNESP]-
Autor(es): dc.creatorMoreira, Cristiane M. [UNESP]-
Autor(es): dc.creatorde Aquino, Ariana M. [UNESP]-
Autor(es): dc.creatorAlonso-Costa, Luiz G. [UNESP]-
Autor(es): dc.creatorBidinotto, Lucas T. [UNESP]-
Autor(es): dc.creatorKass, Laura-
Autor(es): dc.creatorFlaws, Jodi A.-
Autor(es): dc.creatorScarano, Wellerson R. [UNESP]-
Autor(es): dc.creatorBarbisan, Luis F. [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:11:59Z-
Data de disponibilização: dc.date.available2022-08-04T22:11:59Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-10-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.fct.2021.112519-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222275-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222275-
Descrição: dc.descriptionPhthalates metabolites have been detected in the urine of pregnant and breastfeeding women. Thus, this study evaluated the adverse effects of maternal exposure to a mixture of six phthalates (Pth mix) on the mammary gland development and carcinogenesis in F1 female offspring. Pregnant female Sprague-Dawley rats were exposed daily to vehicle or Pth mix (35.22% diethyl-phthalate, 21.03% di-(2-ethylhexyl)-phthalate, 14.91% dibutyl-phthalate, 15.10% diisononyl-phthalate, 8.61% diisobutyl-phthalate, and 5.13% benzylbutyl-phthalate) by gavage at 20 μg/kg, 200 μg/kg or 200 mg/kg during gestational day 10 (GD 10) to postnatal day 21 (PND 21). After weaning (PND 22), some female offspring were euthanized for mammary gland analyses while other females received a single dose of N-methyl-N-nitrosourea (MNU, 50 mg/kg) or vehicle and then tumor incidence and multiplicity were recorded until PND 180. Maternal Pth mix exposure increased the number of Ki-67 and progesterone receptor-positive epithelial cells in the mammary gland from Pth mix 200 at μg/kg and 200 mg/kg groups. In addition, tumor incidence and mean number were higher only in Pth mix at 200 mg/kg when compared to the vehicle-treated group, and percentage of tumor-free animals was lower in Pth mix at 200 μg/kg and 200 mg/kg groups. The findings indicate that perinatal Pth mixture exposure increased susceptibility to MNU-induced mammary carcinogenesis in adult F1 female offspring.-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology School of Medicine Sao Paulo State University (UNESP)-
Descrição: dc.descriptionBarretos School of Health Sciences Dr. Paulo Prata – FACISB-
Descrição: dc.descriptionMolecular Oncology Research Center Barretos Cancer Hospital-
Descrição: dc.descriptionInstituto de Salud y Ambiente del Litoral (ISAL UNL-CONICET) Facultad de Bioquímica y Ciencias Biológicas Ciudad Universitaria UNL-
Descrição: dc.descriptionDepartment of Comparative Biosciences University of Illinois at Urbana-Champaign-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology School of Medicine Sao Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationFood and Chemical Toxicology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectChemically-induced mammary tumor-
Palavras-chave: dc.subjectF1female offspring-
Palavras-chave: dc.subjectMammary gland development and cancer susceptibility-
Palavras-chave: dc.subjectPhthalate mixture-
Título: dc.titlePrenatal exposure to a mixture of different phthalates increases the risk of mammary carcinogenesis in F1 female offspring-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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