Morphological Changes in the Myotendinous Junction of mdx Mice

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.creatorMartinez, Giovana Zerbo [UNESP]-
Autor(es): dc.creatorGrillo, Bruna Aléxia Cristofoletti [UNESP]-
Autor(es): dc.creatorRocha, Lara Caetano [UNESP]-
Autor(es): dc.creatorJacob, Carolina Dos Santos [UNESP]-
Autor(es): dc.creatorPimentel Neto, Jurandyr [UNESP]-
Autor(es): dc.creatorTomiate, André Neri [UNESP]-
Autor(es): dc.creatorBarbosa, Gabriela Klein [UNESP]-
Autor(es): dc.creatorWatanabe, Ii-Sei-
Autor(es): dc.creatorCiena, Adriano Polican [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:11:54Z-
Data de disponibilização: dc.date.available2022-08-04T22:11:54Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-10-17-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1017/S1431927621012496-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222253-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222253-
Descrição: dc.descriptionThe myotendinous junction (MTJ) is the interface between muscle and tendon, and it is the main area of force transmission of the locomotor apparatus. Dystrophic processes promote pathological injury which affects the skeletal muscle and can influence the morphology of the MTJ. This study aimed to investigate the adaptations in MTJ morphology of mdx mice in the tibialis anterior muscle. Male mice (n = 24) were divided into Control-C57bl/10 and mdx-C57bl/10mdx (Duchenne muscular dystrophy experimental model). In the mdx group, centralized nuclei with a large area and greater deposition of type III collagen (fibrosis) were observed. Also, shorter sarcomeres and sarcoplasmatic projections of MTJ were observed. We concluded that the adaptations in mdx mice demonstrated extensive impairment in the MTJ region with reduced ultrastructures.-
Descrição: dc.descriptionLaboratory of Morphology and Physical Activity (LAMAF) São Paulo State University (UNESP) Institute of Biosciences (IB), Avenue 24A, n. 1515, SP-
Descrição: dc.descriptionDepartment of Anatomy Institute of Biomedical Sciences Iii University of São Paulo (USP)-
Descrição: dc.descriptionLaboratory of Morphology and Physical Activity (LAMAF) São Paulo State University (UNESP) Institute of Biosciences (IB), Avenue 24A, n. 1515, SP-
Formato: dc.format1290-1294-
Idioma: dc.languageen-
Relação: dc.relationMicroscopy and Microanalysis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDuchenne muscular dystrophy-
Palavras-chave: dc.subjectfibrosis-
Palavras-chave: dc.subjectfinger-like process-
Palavras-chave: dc.subjectmuscle degeneration-
Palavras-chave: dc.subjectsarcomere-
Título: dc.titleMorphological Changes in the Myotendinous Junction of mdx Mice-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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