Antileishmanial activity evaluation of poly(thymolformaldehyde)—A biobased material from thymol

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal do ABC (UFABC)-
Autor(es): dc.creatorParolin, Giovana A.-
Autor(es): dc.creatorPassero, Luiz Felipe D. [UNESP]-
Autor(es): dc.creatorLago, João Henrique G.-
Autor(es): dc.creatorPéres, Laura Oliveira-
Data de aceite: dc.date.accessioned2022-08-04T22:11:51Z-
Data de disponibilização: dc.date.available2022-08-04T22:11:51Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-10-31-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.indcrop.2021.113935-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222233-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222233-
Descrição: dc.descriptionA new biobased compound was prepared from commercially available monoterpene thymol, obtained from the essential oil of a cultivated plant, Thymus vulgaris L. (Lamiaceae), together with formaldehyde. The final product, poly(thymolformaldehyde), namely PTF, was characterized by infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), UV–vis spectroscopy, fluorescence, gel permeation chromatography (GPC), thermogravimetric analysis (TGA), and differential scattering calorimetry (DSC). NMR associated with FTIR data analysis evidenced the occurrence of polymerization at C-1 and C-5 positions of thymol. UV–vis and fluorescence analysis showed that the prepared material exhibited absorption and emission bands at 285 and 313 nm, respectively. GPC data analysis displayed a polydisperse material (PDI = 1.99) with a molar mass of approximately 1375 Da, while TGA analysis showed a high thermal resistance (ranging from 150 to 800 °C). PTF was evaluated against promastigote forms of Leishmania (Leishmania) amazonensis and exhibited effective concentration 50 % (EC50) of 8.4 ± 0.8 μg/mL as well as reduced toxicity to macrophages (cytotoxic concentration 50 % - CC50 > 100 μg/mL and SI > 11.9). Therefore, the effects of PTF against L. (L.) amazonensis, together with its simple preparation using commercially available reagents (thymol and formaldehyde), suggest that this polymer could be a promising candidate for new biobased drugs to treat cutaneous leishmaniasis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionLaboratory of Hybrid Materials Chemistry Department Federal University of São Paulo (UNIFESP)-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute for Advanced Studies of Ocean São Paulo State University (UNESP)-
Descrição: dc.descriptionLaboratory of Chemical Biology Center for Natural and Human Sciences Federal University of ABC (UFABC)-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute for Advanced Studies of Ocean São Paulo State University (UNESP)-
Descrição: dc.descriptionFAPESP: 2014/50869-6-
Descrição: dc.descriptionFAPESP: 2018/04340-4-
Descrição: dc.descriptionFAPESP: 2018/07885-1-
Descrição: dc.descriptionFAPESP: 2018/18180-9-
Descrição: dc.descriptionFAPESP: 2018/24077-6-
Descrição: dc.descriptionCAPES: 23038.000776/201754-
Descrição: dc.descriptionCNPq: 308686/2017-9-
Descrição: dc.descriptionCNPq: 401109/2014-3-
Idioma: dc.languageen-
Relação: dc.relationIndustrial Crops and Products-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiobased material-
Palavras-chave: dc.subjectLeishmania (L.) amazonensis-
Palavras-chave: dc.subjectPolymerization-
Palavras-chave: dc.subjectThymol-
Título: dc.titleAntileishmanial activity evaluation of poly(thymolformaldehyde)—A biobased material from thymol-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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