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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
Autor(es): dc.contributor | ONCO CANE-Veterinary | - |
Autor(es): dc.contributor | VetPat Veterinary Laboratory | - |
Autor(es): dc.contributor | Federal University of Fronteira Sul—UFFS | - |
Autor(es): dc.contributor | Paulista University—UNIP | - |
Autor(es): dc.creator | Rozolen, Juliana Moreira [UNESP] | - |
Autor(es): dc.creator | Teodoro, Tamires Goneli Wichert [UNESP] | - |
Autor(es): dc.creator | Sobral, Renata Afonso | - |
Autor(es): dc.creator | Sueiro, Felipe Augusto Ruiz | - |
Autor(es): dc.creator | Laufer-Amorim, Renee [UNESP] | - |
Autor(es): dc.creator | Elias, Fabiana | - |
Autor(es): dc.creator | Fonseca-Alves, Carlos Eduardo [UNESP] | - |
Data de aceite: dc.date.accessioned | 2022-08-04T22:11:44Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T22:11:44Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2021-08-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.3390/ani11082406 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/222190 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/222190 | - |
Descrição: dc.description | Splenic hemangiosarcoma (HSA) is a malignant tumor of endothelial cells that affects middle-aged and elderly dogs and is characterized by the formation of new blood vessels, commonly associated with necrotic and hemorrhagic areas. Despite its importance in veterinary medicine, few studies have identified markers with prognostic value for canine HSA. Thus, this study aimed to associate the clinicopathological findings (prostate-specific membrane antigen [PSMA], Claudin-5, and Ki67 gene and protein expression) with overall survival in HSA-affected patients. Fifty-three formalin-fixed and paraffin-embedded canine splenic HSA samples, previously diagnosed by histopathological examination, were used in this study. Claudin-5, PSMA, and Ki67 protein expression levels were evaluated by immunohistochemistry, and gene expression was evaluated by quantitative polymerase chain reaction. Claudin-5 protein overexpression was observed in patients with metastasis (p = 0.0078) and with stage III tumors compared to those with stage I and II tumors (p = 0.0451). In patients treated with surgery alone, low PSMA gene and protein expression (p = 0.05 and p = 0.0355, respectively) were associated with longer survival time. Longer survival time was observed in patients with a low Ki67 index (p = 0.0488). Our results indicate that Claudin-5 protein expression is associated with metastatic status, and PSMA gene and protein expression, and Ki67 index are associated with survival time. | - |
Descrição: dc.description | Department of Veterinary Surgery and Animal Reproduction Sao Paulo State University—UNESP | - |
Descrição: dc.description | Department of Veterinary Clinic Sao Paulo State University—UNESP | - |
Descrição: dc.description | ONCO CANE-Veterinary | - |
Descrição: dc.description | VetPat Veterinary Laboratory | - |
Descrição: dc.description | Veterinary School Federal University of Fronteira Sul—UFFS | - |
Descrição: dc.description | Institute of Health Sciences Paulista University—UNIP | - |
Descrição: dc.description | Department of Veterinary Surgery and Animal Reproduction Sao Paulo State University—UNESP | - |
Descrição: dc.description | Department of Veterinary Clinic Sao Paulo State University—UNESP | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Animals | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Canine spleen neoplasia | - |
Palavras-chave: dc.subject | Endothelial splenic neoplasia | - |
Palavras-chave: dc.subject | Ki67 | - |
Palavras-chave: dc.subject | Proliferative index | - |
Palavras-chave: dc.subject | Prostate-specific membrane antigen | - |
Título: dc.title | Investigation of prognostic value of claudin-5, psma, and ki67 expression in canine splenic hemangiosarcoma | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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