Going further post-RNA-seq: In silico functional analyses revealing candidate genes and regulatory elements related to mastitis in dairy cattle

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Autor(es): dc.contributorUniversidade Federal de Juiz de Fora-
Autor(es): dc.contributorUniversidade Federal Dos Vales Do Jequitinhonha e Mucuri-
Autor(es): dc.contributorUniversidade Federal do Espírito Santo (UFES)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
Autor(es): dc.creatorPasse Pereira, Hyago-
Autor(es): dc.creatorLima Verardo, Lucas-
Autor(es): dc.creatorMorena Del Cambre Amaral Weller, Mayara-
Autor(es): dc.creatorPaula Sbardella, Ana [UNESP]-
Autor(es): dc.creatorPrado Munari, Danísio [UNESP]-
Autor(es): dc.creatorMorais De Paiva Daibert, Raquel-
Autor(es): dc.creatorAraújo Carvalho, Wanessa-
Autor(es): dc.creatorAntonio Machado, Marco-
Autor(es): dc.creatorFonseca Martins, Marta-
Data de aceite: dc.date.accessioned2022-08-04T22:11:41Z-
Data de disponibilização: dc.date.available2022-08-04T22:11:41Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1017/S0022029921000571-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222184-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222184-
Descrição: dc.descriptionThis study aimed to obtain a better understanding of the regulatory genes and molecules involved in the development of mastitis. For this purpose, the transcription factors (TF) and MicroRNAs (miRNA) related to differentially expressed genes previously found in extracorporeal udders infected with Streptococcus agalactiae were investigated. The Gene-TF network highlighted LOC515333, SAA3, CD14, NFKBIA, APOC2 and LOC100335608 and genes that encode the most representative transcription factors STAT3, PPARG, EGR1 and NFKB1 for infected udders. In addition, it was possible to highlight, through the analysis of the gene-miRNA network, genes that could be post-transcriptionally regulated by miRNAs, such as the relationship between the CCL5 gene and the miRNA bta-miR-363. Overall, our data demonstrated genes and regulatory elements (TF and miRNA) that can play an important role in mastitis resistance. The results provide new insights into the first functional pathways and the network of genes that orchestrate the innate immune responses to infection by Streptococcus agalactiae. Our results will increase the general knowledge about the gene networks, transcription factors and miRNAs involved in fighting intramammary infection and maintaining tissue during infection and thus enable a better understanding of the pathophysiology of mastitis.-
Descrição: dc.descriptionInstitute of Biological Sciences Universidade Federal de Juiz de Fora-
Descrição: dc.descriptionZootechnics Department Universidade Federal Dos Vales Do Jequitinhonha e Mucuri-
Descrição: dc.descriptionZootechnics Department Universidade Federal Do Espírito Santo-
Descrição: dc.descriptionDepartment of Exact Sciences Universidade Estadual Paulista Júlio de Mesquita Filho-
Descrição: dc.descriptionMolecular Genetics Laboratory Embrapa Gado de Leite-
Descrição: dc.descriptionDepartment of Exact Sciences Universidade Estadual Paulista Júlio de Mesquita Filho-
Formato: dc.format286-292-
Idioma: dc.languageen-
Relação: dc.relationJournal of Dairy Research-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBovine-
Palavras-chave: dc.subjectextracorporeal udders-
Palavras-chave: dc.subjectmastitis-
Palavras-chave: dc.subjectMicroRNA-
Palavras-chave: dc.subjecttranscription factors-
Título: dc.titleGoing further post-RNA-seq: In silico functional analyses revealing candidate genes and regulatory elements related to mastitis in dairy cattle-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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