An in silico, structural, and biological analysis of lactoferrin of different mammals

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Federal de Viçosa (UFV)-
Autor(es): dc.contributorTechnological University Dublin-
Autor(es): dc.contributorUniversity of Nebraska – Lincoln-
Autor(es): dc.contributorUniversidade Federal de Goiás (UFG)-
Autor(es): dc.creatorda S. Vieira, Dielson [UNESP]-
Autor(es): dc.creatorPolveiro, Richard C.-
Autor(es): dc.creatorButler, Thomas J.-
Autor(es): dc.creatorHackett, Timothy A.-
Autor(es): dc.creatorBraga, Camila P.-
Autor(es): dc.creatorPuniya, Bhanwar Lal-
Autor(es): dc.creatorTeixeira, Weslen F.P.-
Autor(es): dc.creatorde M. Padilha, Pedro [UNESP]-
Autor(es): dc.creatorAdamec, Jiri-
Autor(es): dc.creatorFeitosa, Francisco L.F. [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:11:30Z-
Data de disponibilização: dc.date.available2022-08-04T22:11:30Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-09-30-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.ijbiomac.2021.07.102-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222128-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222128-
Descrição: dc.descriptionLactoferrin (LF) belongs to the family of transferrins having multifunctional roles associated with the immune system of animals. To follow the aims for this study was selected 20 sequences of LF from mammalian species to evaluate the chemical, biological, and structural properties. Bioinformatics approaches used programs such as MAFFT for sequence alignment; PartitionFinder and MrBayes for phylogenetic approaches; I-TASSER, PROCHECK, Molecular Operating Environment (MOE), SWISS Model server, Peptide DB and Expasy ProtParam to estimate the physicochemical properties, to model the protein and predicted secondary structures. A phylogenic analysis shows species with genetic similarities clustered by complexity and unique grouping between Capra hircus, Macaca mulatta, and Myotis lucifugus, since they presented more amino acids but not overall changes in the iron-binding sites or biological aspects. Structural deviations in these clusters obtained in LF from those species were found in residues 46 (position 406-450), that is part of alpha-helix, and 37 (position 295-331), that is part of the beta-sheets. Our predicted model can be used to investigate more about structural aspects of LF and be applied for medicinal research.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionSão Paulo State University “Júlio de Mesquita Filho” (UNESP) School of Veterinary Medicine-
Descrição: dc.descriptionFederal University of Viçosa (UFV) Veterinary Department-
Descrição: dc.descriptionEnvironmental Sustainability and Health Institute (ESHI) School of Biological and Health Sciences Technological University Dublin-
Descrição: dc.descriptionDepartment of Biochemistry University of Nebraska – Lincoln-
Descrição: dc.descriptionFederal University of Goiás (UFG) Department of Veterinary Medicine-
Descrição: dc.descriptionSão Paulo State University “Júlio de Mesquita Filho” (UNESP) Biosciences Institute-
Descrição: dc.descriptionSão Paulo State University “Júlio de Mesquita Filho” (UNESP) School of Veterinary Medicine-
Descrição: dc.descriptionSão Paulo State University “Júlio de Mesquita Filho” (UNESP) Biosciences Institute-
Descrição: dc.descriptionFAPESP: 2017/22041-1-
Descrição: dc.descriptionFAPESP: 2019/02781-6-
Formato: dc.format119-126-
Idioma: dc.languageen-
Relação: dc.relationInternational Journal of Biological Macromolecules-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectGlobular glycoprotein-
Palavras-chave: dc.subjectIn silico-
Palavras-chave: dc.subjectLactotransferrin-
Palavras-chave: dc.subjectMammalians-
Palavras-chave: dc.subjectMilk proteins-
Título: dc.titleAn in silico, structural, and biological analysis of lactoferrin of different mammals-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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