Rice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorSiqueira, Juliana Silva [UNESP]-
Autor(es): dc.creatorFrancisqueti-Ferron, Fabiane Valentini [UNESP]-
Autor(es): dc.creatorGarcia, Jéssica Leite [UNESP]-
Autor(es): dc.creatorSilva, Carol Cristina Vágula de Almeida [UNESP]-
Autor(es): dc.creatorCosta, Mariane Róvero [UNESP]-
Autor(es): dc.creatorNakandakare-Maia, Erika Tiemi [UNESP]-
Autor(es): dc.creatorMoreto, Fernando [UNESP]-
Autor(es): dc.creatorFerreira, Ana Lúcia A [UNESP]-
Autor(es): dc.creatorMinatel, Igor Otávio [UNESP]-
Autor(es): dc.creatorFerron, Artur Junio Togneri [UNESP]-
Autor(es): dc.creatorCorrêa, Camila Renata [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:11:29Z-
Data de disponibilização: dc.date.available2022-08-04T22:11:29Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/2175-8239-JBN-2020-0169-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222121-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222121-
Descrição: dc.descriptionINTRODUCTION: Obesity, diabetes, and hypertension are common risk factors for chronic kidney disease (CKD). CKD arises due to many pathological insults, including inflammation and oxidative stress, which affect renal function and destroy nephrons. Rice bran (RB) is rich in vitamins and minerals, and contains significant amount of antioxidants. The aim of this study was to evaluate the preventive effect of RB on renal disease risk factors. METHODS: Male Wistar rats (±325 g) were divided into two experimental groups to received a high sugar-fat diet (HSF, n = 8) or high sugar-fat diet with rice bran (HSF + RB, n = 8) for 20 weeks. At the end, renal function, body composition, metabolic parameters, renal inflammatory and oxidative stress markers were analyzed. RESULTS: RB prevented obesity [AI (HSF= 9.92 ± 1.19 vs HSF + RB= 6.62 ± 0.78)], insulin resistance [HOMA (HSF= 83 ± 8 vs. HSF + RB= 42 ± 11)], dyslipidemia [TG (HSF= 167 ± 41 vs. HSF + RB=92 ± 40)], inflammation [TNF-α (HSF= 80 ± 12 vs. HSF + RB=57 ± 14), IL-6 (903 ± 274 vs. HSF + RB=535 ± 277)], oxidative stress [protein carbonylation (HSF= 3.38 ± 0.18 vs. HSF + RB=2.68 ± 0.29), RAGE (HSF=702 ± 36 vs. RSF + RB=570 ± 190)], and renal disease [protein/creatinine ratio (HSF=1.10 ± 0.38 vs. HSF + RB=0.49 ± 0.16)]. CONCLUSION: In conclusion, rice bran prevented renal disease by modulating risk factors.-
Descrição: dc.descriptionUniversidade Estadual Paulista Instituto de Biociências-
Descrição: dc.descriptionUniversidade Estadual Paulista Faculdade de Medicina-
Descrição: dc.descriptionUniversidade Estadual Paulista Instituto de Biociências-
Descrição: dc.descriptionUniversidade Estadual Paulista Faculdade de Medicina-
Formato: dc.format156-164-
Idioma: dc.languageen-
Idioma: dc.languagept_BR-
Relação: dc.relationJornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia-
???dc.source???: dc.sourceScopus-
Título: dc.titleRice bran modulates renal disease risk factors in animals submitted to high sugar-fat diet-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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