High prevalence of biochemical disturbances of chronic kidney disease - mineral and bone disorders (CKD-MBD) in a nation-wide peritoneal dialysis cohort: are guideline goals too hard to achieve?

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorPR-
Autor(es): dc.contributorUniversidade Federal do Paraná (UFPR)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorRS-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorWeissheimer, Rafael-
Autor(es): dc.creatorBucharles, Sergio Gardano Elias-
Autor(es): dc.creatorTruyts, Cesar Augusto Madid-
Autor(es): dc.creatorJorgetti, Vanda-
Autor(es): dc.creatorFigueiredo, Ana Elizabeth-
Autor(es): dc.creatorBarrett, Pasqual [UNESP]-
Autor(es): dc.creatorOlandoski, Marcia-
Autor(es): dc.creatorPecoits-Filho, Roberto-
Autor(es): dc.creatorMoraes, Thyago Proença de-
Data de aceite: dc.date.accessioned2022-08-04T22:11:28Z-
Data de disponibilização: dc.date.available2022-08-04T22:11:28Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-04-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/2175-8239-JBN-2020-0147-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/222120-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/222120-
Descrição: dc.descriptionINTRODUCTION: Chronic kidney disease - mineral and bone disorders (CKD-MBD) are common in dialysis patients. Definition of targets for calcium (Ca), phosphorus (P), parathormone (iPTH), and alkaline phosphatase (ALP) and their treatment recommendations, are provided by international guidelines. There are few studies analyzing CKD-MBD in peritoneal dialysis (PD) patients and the impact of guidelines on mineral metabolism control. The aim of our study was to describe the prevalence of biomarkers for CKD-MBD in a large cohort of PD patients in Brazil. METHODS: Data from the nation-wide prospective observational cohort BRAZPD II was used. Incident patients were followed between December 2004 and January 2011. According to KDOQI recommendations, reference ranges for total Ca were 8.4 to 9.5 mg/dL, for P, 3.5 to 5.5 mg/dL, for iPTH, 150-300 pg/mL, and for ALP, 120 U/L. RESULTS: Mean age was 59.8 ± 16 years, 48% were male, and 43% had diabetes. In the beginning, Ca was 8.9 ± 0.9 mg/dL, and 48.3% were on the KODQI target. After 1 year, Ca increased to 9.1 ± 0.9 mg/dL and 50.4% were in the KDOQI preferred range. P at baseline was 5.2 ± 1.6 mg/dL, with 52.8% on target, declining to 4.9 ± 1.5 mg/dL after one year, when 54.7% were on target. Median iPTH at baseline was 238 (P25% 110 - P75% 426 pg/mL) and it remained stable throughout the first year; patients within target ranged from 26 to 28.5%. At the end of the study, 80% was in 3.5 meq/L Ca dialysate concentration, 66.9% of patients was taking any phosphate binder, and 25% was taking activated vitamin D. CONCLUSIONS: We observed a significant prevalence of biochemical disorders related to CKD-MBD in this dialysis population.-
Descrição: dc.descriptionPontifícia Universidade Católica do Paraná Escola de Medicina PR-
Descrição: dc.descriptionUniversidade Federal do Paraná PR-
Descrição: dc.descriptionUniversidade de São Paulo Escola de Medicina-
Descrição: dc.descriptionPontifícia Universidade Católica do Rio Grande do Sul Programa de Pós-Graduação em Medicina e Ciências da Saúde RS-
Descrição: dc.descriptionUniversidade Estadual de São Paulo Escola de Medicina-
Descrição: dc.descriptionUniversidade Estadual de São Paulo Escola de Medicina-
Formato: dc.format173-181-
Idioma: dc.languageen-
Idioma: dc.languagept_BR-
Relação: dc.relationJornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia-
???dc.source???: dc.sourceScopus-
Título: dc.titleHigh prevalence of biochemical disturbances of chronic kidney disease - mineral and bone disorders (CKD-MBD) in a nation-wide peritoneal dialysis cohort: are guideline goals too hard to achieve?-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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