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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine | - |
Autor(es): dc.contributor | Sichuan University | - |
Autor(es): dc.contributor | University of Amsterdam and Vrije Universiteit Amsterdam | - |
Autor(es): dc.contributor | Universidade Federal de São Carlos (UFSCar) | - |
Autor(es): dc.contributor | Universidade de São Paulo (USP) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
Autor(es): dc.creator | Nie, Min | - |
Autor(es): dc.creator | Silva, Rodrigo Costa e | - |
Autor(es): dc.creator | de Oliveira, Kleber Thiago | - |
Autor(es): dc.creator | Bagnato, Vanderlei Salvador | - |
Autor(es): dc.creator | de Souza Rastelli, Alessandra Nara [UNESP] | - |
Autor(es): dc.creator | Crielaard, Wim | - |
Autor(es): dc.creator | Yang, Jingmei | - |
Autor(es): dc.creator | Deng, Dong Mei | - |
Data de aceite: dc.date.accessioned | 2022-08-04T22:11:27Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T22:11:27Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2020-12-31 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1080/08927014.2021.1954169 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/222112 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/222112 | - |
Descrição: dc.description | Antimicrobial photodynamic therapy (aPDT) has been considered as a potential alternative to antibiotics for the treatment of biofilm infections. There is evidence that an additional H2O2 enhances the antimicrobial efficacy of aPDT. However, the minimum H2O2 concentration to achieve this synergistic effect is unclear. A saliva-derived multi-species biofilm was treated with the photosensitizer chlorin e6 (Ce6, 50 µM), H2O2 (0.3, 3.3, 33.3 mM), or their combination for 5 min, followed by no irradiation or irradiation at 15 J (cm2)−1 (λ = 450 nm or 660 nm), with or without oxygen. Biofilm viability and metabolic activity were evaluated. The combination of 33.3 mM H2O2 and Ce6-aPDT strongly enhanced antimicrobial efficacy compared with either component alone, irrespective of oxygen availability and irradiation wavelength. In particular, the combination resulted in a 6.6-log colony forming unit (CFU) reduction anaerobically under blue irradiation. This combination is a promising treatment for biofilm infections, especially those thriving in an anaerobic microenvironment. | - |
Descrição: dc.description | Department of Periodontics Affiliated Stomatology Hospital of Guangzhou Medical University Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine | - |
Descrição: dc.description | State Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases Department of Periodontics West China Hospital of Stomatology Sichuan University | - |
Descrição: dc.description | Department of Preventive Dentistry Academic Centre for Dentistry Amsterdam University of Amsterdam and Vrije Universiteit Amsterdam | - |
Descrição: dc.description | Department of Chemistry Federal University of São Carlos–UFSCar | - |
Descrição: dc.description | São Carlos Institute of Physics University of São Paulo-USP São Carlos | - |
Descrição: dc.description | Department of Restorative Dentistry School of Dentistry São Paulo State University-UNESP | - |
Descrição: dc.description | Department of Restorative Dentistry School of Dentistry São Paulo State University-UNESP | - |
Formato: dc.format | 656-665 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Biofouling | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | biofilm | - |
Palavras-chave: dc.subject | chlorin e6 | - |
Palavras-chave: dc.subject | hydrogen peroxide | - |
Palavras-chave: dc.subject | oxygen | - |
Palavras-chave: dc.subject | Photodynamic therapy | - |
Título: dc.title | Synergetic antimicrobial effect of chlorin e6 and hydrogen peroxide on multi-species biofilms | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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