Transcriptomic landscape of male and female reproductive cancers: Similar pathways and molecular signatures predicting response to endocrine therapy

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorEmory University School of Medicine-
Autor(es): dc.creatorCamargo, Ana CL. [UNESP]-
Autor(es): dc.creatorRemoli, Beatriz [UNESP]-
Autor(es): dc.creatorPortela, Luiz MF. [UNESP]-
Autor(es): dc.creatorFioretto, Mateus N. [UNESP]-
Autor(es): dc.creatorChuffa, Luiz GA. [UNESP]-
Autor(es): dc.creatorMoreno, Carlos S.-
Autor(es): dc.creatorJustulin, Luis A. [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:10:19Z-
Data de disponibilização: dc.date.available2022-08-04T22:10:19Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-09-15-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.mce.2021.111393-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221936-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221936-
Descrição: dc.descriptionReproductive cancers in both genders represent serious health problems, whose incidence has significantly risen over the past decades. Although considerable differences among reproductive cancers exist, we aimed to identify similar signaling pathways and key molecular oncomarkers shared among six human reproductive cancers that can advance the current knowledge of cancer biology to propose new strategies for more effective therapies. Using a computational analysis approach, here we uncover aberrant miRNAs-mRNAs networks shared in six reproductive tumor types, and identify common molecular mechanisms strictly associated with cancer promotion and aggressiveness. Based on the fact that estrogenic and androgenic signaling pathways were most active in prostate and breast cancers, we further demonstrated that both androgen and estrogen deprivation therapy are capable of regulating the expression of the same key molecular sensors associated with endoplasmic reticulum dysfunction and cell cycle in these cancers. Overall, our data reveal a potential mechanistic framework of cellular processes that are shared among reproductive cancers, and particularly, highlight the importance of hormonal deprivation in breast and prostate cancers and potentially new biomarkers of response to these therapeutic approaches.-
Descrição: dc.descriptionASCRS Research Foundation-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionDepartment of Pathology and Laboratory Medicine Emory University School of Medicine, Georgia-
Descrição: dc.descriptionDepartment of Biomedical Informatics Emory University School of Medicine, Georgia-
Descrição: dc.descriptionDepartment of Structural and Functional Biology Institute of Biosciences Sao Paulo State University (UNESP)-
Descrição: dc.descriptionCNPq: # 310-
Descrição: dc.descriptionFAPESP: 2016/2017/01063-
Descrição: dc.descriptionFAPESP: 2017/08715–0-
Descrição: dc.descriptionCNPq: 663/2018–0-
Descrição: dc.descriptionFAPESP: 7/2018/09408–6-
Idioma: dc.languageen-
Relação: dc.relationMolecular and Cellular Endocrinology-
???dc.source???: dc.sourceScopus-
Título: dc.titleTranscriptomic landscape of male and female reproductive cancers: Similar pathways and molecular signatures predicting response to endocrine therapy-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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