Automated method to determine pharmaceutical compounds in wastewater using on-line solid-phase extraction coupled to LC-MS/MS

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Florida-
Autor(es): dc.creatorMarasco Júnior, César Augusto [UNESP]-
Autor(es): dc.creatorda Silva, Bianca Ferreira [UNESP]-
Autor(es): dc.creatorLamarca, Rafaela Silva [UNESP]-
Autor(es): dc.creatorde Lima Gomes, Paulo Clairmont Feitosa [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:10:00Z-
Data de disponibilização: dc.date.available2022-08-04T22:10:00Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s00216-021-03481-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221848-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221848-
Descrição: dc.descriptionAn automated method was developed using on-line solid-phase extraction (SPE) as a sample preparation step, coupled to liquid chromatography-tandem mass spectrometry (LC-MS/MS), for determination of pharmaceutical compounds in wastewater samples at nanograms per liter to micrograms per liter concentration levels. This method is suitable for use in routine analysis, especially in environmental applications, avoiding cross-contamination and requiring minimal sample handling. Results can be obtained rapidly, with a chromatographic run time of only 24 min (including sample preparation and chromatographic analysis). Using a 50 μL injection volume, the method was validated according to international guidelines, considering parameters included in terms of method detection (MDL) and quantification limit (MQL), linearity, inter-day and intra-day precisions, and matrix effects. Assessment of chromatographic efficiency considered peak resolution and asymmetry, and carryover was evaluated to ensure analytical reliability and the ability to reuse the SPE cartridge. The intra- and inter-day precisions were lower than 10 and 17%, respectively. The MDL values ranged from 1×10-6 to 1 μg L-1, while the MQL values were from 0.001 to 3 μg L-1. Matrix effects were minimized by isotope dilution calibration. Application of the method to 20 wastewater samples showed that caffeine was the most frequently detected compound, with the highest concentration of 715 μg L-1, while other pharmaceutical compounds were detected in fewer samples and at lower concentrations (up to 8.51 μg L-1). Graphical abstract: [Figure not available: see fulltext.]-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry São Paulo State University, P.O. Box 355-
Descrição: dc.descriptionCollege of Veterinary Medicine Department of Physiological Sciences University of Florida, P.O. Box 490-
Descrição: dc.descriptionNational Institute for Alternative Technologies of Detection Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM) Institute of Chemistry São Paulo State University, P.O. Box 355-
Descrição: dc.descriptionFAPESP: #18/11700-7-
Descrição: dc.descriptionFAPESP: #18/2239-
Descrição: dc.descriptionCNPq: #465571/2014-0-
Descrição: dc.descriptionCAPES: #88887136426/2017/00-
Descrição: dc.descriptionFAPESP: grants #16/03369-3-
Formato: dc.format5147-5160-
Idioma: dc.languageen-
Relação: dc.relationAnalytical and Bioanalytical Chemistry-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectEmerging contaminants-
Palavras-chave: dc.subjectLiquid chromatography-tandem mass spectrometry-
Palavras-chave: dc.subjectOn-line sample preparation-
Palavras-chave: dc.subjectPharmaceutical compounds-
Palavras-chave: dc.subjectWastewater analysis-
Título: dc.titleAutomated method to determine pharmaceutical compounds in wastewater using on-line solid-phase extraction coupled to LC-MS/MS-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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