Mechanistic Insights into the Leishmanicidal and Bactericidal Activities of Batroxicidin, a Cathelicidin-Related Peptide from a South American Viper (Bothrops atrox)

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversity of Brasilia-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversity of Guarulhos-
Autor(es): dc.contributorUniversity of Porto-
Autor(es): dc.contributorUniversidade de Lisboa-
Autor(es): dc.contributorFaculty of Sciences of the University of Porto-
Autor(es): dc.contributorAalborg University-
Autor(es): dc.contributorUniversity of Lincoln-
Autor(es): dc.creatorDematei, Anderson-
Autor(es): dc.creatorNunes, João B.-
Autor(es): dc.creatorMoreira, Daniel C.-
Autor(es): dc.creatorJesus, Jéssica A. [UNESP]-
Autor(es): dc.creatorLaurenti, Márcia D.-
Autor(es): dc.creatorMengarda, Ana C. A.-
Autor(es): dc.creatorVieira, Maria Silva-
Autor(es): dc.creatorDo Amaral, Constança Pais-
Autor(es): dc.creatorDomingues, Marco M.-
Autor(es): dc.creatorDe Moraes, Josué-
Autor(es): dc.creatorPassero, Luiz F. D. [UNESP]-
Autor(es): dc.creatorBrand, Guilherme-
Autor(es): dc.creatorBessa, Lucinda J.-
Autor(es): dc.creatorWimmer, Reinhard-
Autor(es): dc.creatorKuckelhaus, Selma A. S.-
Autor(es): dc.creatorTomás, Ana M.-
Autor(es): dc.creatorSantos, Nuno C.-
Autor(es): dc.creatorPlácido, Alexandra-
Autor(es): dc.creatorEaton, Peter-
Autor(es): dc.creatorLeite, José Roberto S. A.-
Data de aceite: dc.date.accessioned2022-08-04T22:09:57Z-
Data de disponibilização: dc.date.available2022-08-04T22:09:57Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-06-25-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1021/acs.jnatprod.1c00153-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221833-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221833-
Descrição: dc.descriptionSnake venoms are important sources of bioactive molecules, including those with antiparasitic activity. Cathelicidins form a class of such molecules, which are produced by a variety of organisms. Batroxicidin (BatxC) is a cathelicidin found in the venom of the common lancehead (Bothrops atrox). In the present work, BatxC and two synthetic analogues, BatxC(C-2.15Phe) and BatxC(C-2.14Phe)des-Phe1, were assessed for their microbicidal activity. All three peptides showed a broad-spectrum activity on Gram-positive and-negative bacteria, as well as promastigote and amastigote forms of Leishmania (Leishmania) amazonensis. Circular dichroism (CD) and nuclear magnetic resonance (NMR) data indicated that the three peptides changed their structure upon interaction with membranes. Biomimetic membrane model studies demonstrated that the peptides exert a permeabilization effect in prokaryotic membranes, leading to cell morphology distortion, which was confirmed by atomic force microscopy (AFM). The molecules considered in this work exhibited bactericidal and leishmanicidal activity at low concentrations, with the AFM data suggesting membrane pore formation as their mechanism of action. These peptides stand as valuable prototype drugs to be further investigated and eventually used to treat bacterial and protozoal infections.-
Descrição: dc.descriptionCenter for Tropical Medicine NMT Faculty of Medicine University of Brasilia-
Descrição: dc.descriptionResearch Center in Morphology and Applied Immunology NuPMIA Faculty of Medicine University of Brasilia-
Descrição: dc.descriptionLaboratory for the Synthesis and Analysis of Biomolecules LSAB Institute of Chemistry University of Brasilia-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University-
Descrição: dc.descriptionDepartment of Pathology Laboratory of Pathology of Infectious Diseases Faculty of Medicine University of São Paulo-
Descrição: dc.descriptionResearch Center on Neglected Diseases NPDN University of Guarulhos-
Descrição: dc.descriptionI3S Institute of Research and Innovation in Health University of Porto-
Descrição: dc.descriptionIBMC Institute of Molecular and Cellular Biology University of Porto-
Descrição: dc.descriptionInstituto de Medicina Molecular Faculdade de Medicina Universidade de Lisboa-
Descrição: dc.descriptionLAQV/REQUIMTE Department of Chemistry and Biochemistry Faculty of Sciences of the University of Porto-
Descrição: dc.descriptionDepartment of Chemistry and Bioscience Aalborg University-
Descrição: dc.descriptionICBAS Abel Salazar Institute for Biomedical Research University of Porto-
Descrição: dc.descriptionBridge Joseph Banks Laboratories School of Chemistry University of Lincoln-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University-
Formato: dc.format1787-1798-
Idioma: dc.languageen-
Relação: dc.relationJournal of Natural Products-
???dc.source???: dc.sourceScopus-
Título: dc.titleMechanistic Insights into the Leishmanicidal and Bactericidal Activities of Batroxicidin, a Cathelicidin-Related Peptide from a South American Viper (Bothrops atrox)-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.