Differentiation of porcine induced pluripotent stem cells (Pipscs) into neural progenitor cells (npcs)

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Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMachado, Lucas Simões-
Autor(es): dc.creatorRecchia, Kaiana-
Autor(es): dc.creatorPieri, Naira Caroline Godoy-
Autor(es): dc.creatorBotigelli, Ramon Cesar [UNESP]-
Autor(es): dc.creatorde Castro, Raquel Vasconcelos Guimarães-
Autor(es): dc.creatorCruz, Jéssica Brunhara-
Autor(es): dc.creatorPessôa, Laís Vicari de Figueiredo-
Autor(es): dc.creatorBressan, Fabiana Fernandes-
Data de aceite: dc.date.accessioned2022-08-04T22:09:55Z-
Data de disponibilização: dc.date.available2022-08-04T22:09:55Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-06-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3791/62209-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221821-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221821-
Descrição: dc.descriptioniPSC-derived neurons are attractive in vitro models to study neurogenesis and early phenotypic changes in mental illness, mainly when most animal models used in pre-clinical research, such as rodents, are not able to meet the criteria to translate the findings to the clinic. Non-human primates, canines, and porcine are considered more adequate models for biomedical research and drug development purposes, mainly due to their physiological, genetic, and anatomical similarities to humans. The swine model has gained particular interest in translational neuroscience, enabling safety and allotransplantation testing. Herein the generation of porcine iPSCs is described along with its further differentiation into neural progenitor cells (NPCs). The generated cells expressed NPC markers Nestin and GFAP, confirmed by RT-qPCR, and were positive for Nestin, b-Tubulin III, and Vimentin by immunofluorescence. These results show the evidence for the generation of NPC-like cells after in vitro induction with chemical inhibitors from a large animal model, an interesting and adequate model for regenerative and translational medicine research.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionDepartment of Surgery Faculty of Veterinary Medicine and Animal Sciences University of São Paulo-
Descrição: dc.descriptionDepartment of Veterinary Medicine Faculty of Animal Sciences and Food Engineering University of São Paulo-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences São Paulo State University-
Descrição: dc.descriptionDepartment of Pharmacology Institute of Biosciences São Paulo State University-
Descrição: dc.descriptionCAPES: 001-
Descrição: dc.descriptionFAPESP: 2015/26818-5-
Descrição: dc.descriptionFAPESP: 2017/02159-8-
Descrição: dc.descriptionFAPESP: 2017/13973-8-
Descrição: dc.descriptionCNPq: 433133/2018-0-
Idioma: dc.languageen-
Relação: dc.relationJournal of Visualized Experiments-
???dc.source???: dc.sourceScopus-
Título: dc.titleDifferentiation of porcine induced pluripotent stem cells (Pipscs) into neural progenitor cells (npcs)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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