Modeling the Relationship Between Antibody-Dependent Enhancement and Disease Severity in Secondary Dengue Infection

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Autor(es): dc.contributorUniversité Lyon 1-
Autor(es): dc.contributorUNAM-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorde A. Camargo, Felipe [UNESP]-
Autor(es): dc.creatorAdimy, Mostafa-
Autor(es): dc.creatorEsteva, Lourdes-
Autor(es): dc.creatorMétayer, Clémence-
Autor(es): dc.creatorFerreira, Cláudia P. [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:09:52Z-
Data de disponibilização: dc.date.available2022-08-04T22:09:52Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s11538-021-00919-y-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221805-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221805-
Descrição: dc.descriptionSequential infections with different dengue serotypes (DENV-1, 4) significantly increase the risk of a severe disease outcome (fever, shock, and hemorrhagic disorders). Two hypotheses have been proposed to explain the severity of the disease: (1) antibody-dependent enhancement (ADE) and (2) original T cell antigenic sin. In this work, we explored the first hypothesis through mathematical modeling. The proposed model reproduces the dynamic of susceptible and infected target cells and dengue virus in scenarios of infection-neutralizing and infection-enhancing antibody competition induced by two distinct serotypes of the dengue virus during secondary infection. The enhancement and neutralization functions are derived from basic concepts of chemical reactions and used to mimic binding to the virus by two distinct populations of antibodies. The analytic study of the model showed the existence of two equilibriums: a disease-free equilibrium and an endemic one. Using the concept of the basic reproduction numberR, we performed the asymptotic stability analysis for the two equilibriums. To measure the severity of the disease, we considered the maximum value of infected cells as well as the time when this maximum is reached. We observed that it corresponds to the time when the maximum enhancing activity for the infection occurs. This critical time was calculated from the model to be a few days after the occurrence of the infection, which corresponds to what is observed in the literature. Finally, using as output R, we were able to rank the contribution of each parameter of the model. In particular, we highlighted that the cross-reactive antibody responses may be responsible for the disease enhancement during secondary heterologous dengue infection.-
Descrição: dc.descriptionInria Institut Camille Jordan Université de Lyon Université Lyon 1, 43 Bd. du 11 novembre 1918-
Descrição: dc.descriptionDepartamento de Matemáticas Facultad de Ciencias UNAM-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP)-
Descrição: dc.descriptionInstitute of Biosciences São Paulo State University (UNESP)-
Idioma: dc.languageen-
Relação: dc.relationBulletin of Mathematical Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectDengue hemorrhagic fever (DHF)-
Palavras-chave: dc.subjectDengue shock syndrome (DSS)-
Palavras-chave: dc.subjectDENV1-4-
Palavras-chave: dc.subjectLocal and global stability analyses for ordinary differential system-
Palavras-chave: dc.subjectMathematical modeling-
Palavras-chave: dc.subjectNeutralizing and enhancing antibodies-
Título: dc.titleModeling the Relationship Between Antibody-Dependent Enhancement and Disease Severity in Secondary Dengue Infection-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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