Geography, Host Genetics, and Cross-Domain Microbial Networks Structure the Skin Microbiota of Fragmented Brazilian Atlantic Forest Frog Populations

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Autor(es): dc.contributorUniversity of Michigan-
Autor(es): dc.contributorUniversity of Massachusetts Boston-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.creatorBelasen, Anat M.-
Autor(es): dc.creatorRiolo, Maria A.-
Autor(es): dc.creatorBletz, Molly C.-
Autor(es): dc.creatorLyra, Mariana L. [UNESP]-
Autor(es): dc.creatorToledo, L. Felipe-
Autor(es): dc.creatorJames, Timothy Y.-
Data de aceite: dc.date.accessioned2022-08-04T22:09:46Z-
Data de disponibilização: dc.date.available2022-08-04T22:09:46Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-07-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1002/ece3.7594-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221776-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221776-
Descrição: dc.descriptionThe host-associated microbiome plays a significant role in health. However, the roles of factors such as host genetics and microbial interactions in determining microbiome diversity remain unclear. We examined these factors using amplicon-based sequencing of 175 Thoropa taophora frog skin swabs collected from a naturally fragmented landscape in southeastern Brazil. Specifically, we examined (1) the effects of geography and host genetics on microbiome diversity and structure; (2) the structure of microbial eukaryotic and bacterial co-occurrence networks; and (3) co-occurrence between microeukaryotes with bacterial OTUs known to affect growth of the fungal pathogen Batrachochytrium dendrobatidis (Bd). While bacterial alpha diversity varied by both site type and host MHC IIB genotype, microeukaryotic alpha diversity varied only by site type. However, bacteria and microeukaryote composition showed variation according to both site type and host MHC IIB genotype. Our network analysis showed the highest connectivity when both eukaryotes and bacteria were included, implying that ecological interactions may occur among domains. Lastly, anti-Bd bacteria were not broadly negatively co-associated with the fungal microbiome and were positively associated with potential amphibian parasites. Our findings emphasize the importance of considering both domains in microbiome research and suggest that for effective probiotic strategies for amphibian disease management, considering potential interactions among all members of the microbiome is crucial.-
Descrição: dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionOffice of International Science and Engineering-
Descrição: dc.descriptionDepartment of Ecology and Evolutionary Biology University of Michigan-
Descrição: dc.descriptionCenter for Complex Systems University of Michigan-
Descrição: dc.descriptionDepartment of Biology University of Massachusetts Boston-
Descrição: dc.descriptionInstituto de Biociências Universidade Estadual Paulista-
Descrição: dc.descriptionLaboratório de História Natural de Anfíbios Brasileiros Departamento de Biologia Animal Instituto de Biologia Universidade Estadual de Campinas-
Descrição: dc.descriptionInstituto de Biociências Universidade Estadual Paulista-
Descrição: dc.descriptionCNPq: 300980/2014-0-
Descrição: dc.descriptionCAPES: 88881.062205/2014-01-
Descrição: dc.descriptionOffice of International Science and Engineering: OISE-1159513-
Formato: dc.format9293-9307-
Idioma: dc.languageen-
Relação: dc.relationEcology and Evolution-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectamphibian-
Palavras-chave: dc.subjectBrazil's Atlantic Forest-
Palavras-chave: dc.subjectmicrobial networks-
Palavras-chave: dc.subjectskin microbiome-
Título: dc.titleGeography, Host Genetics, and Cross-Domain Microbial Networks Structure the Skin Microbiota of Fragmented Brazilian Atlantic Forest Frog Populations-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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