Part-time cancers and role of melatonin in determining their metabolic phenotype

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUT Health San Antonio-
Autor(es): dc.contributorFacultad de Medicina-
Autor(es): dc.contributorInstituto Mexicano del Seguro Social-
Autor(es): dc.contributorLaboratorio de Investigacao Molecular do Cancer-
Autor(es): dc.contributorInstituto de Biociencias-
Autor(es): dc.creatorReiter, Russel J.-
Autor(es): dc.creatorSharma, Ramaswamy-
Autor(es): dc.creatorRodriguez, Carmen-
Autor(es): dc.creatorMartin, Vanesa-
Autor(es): dc.creatorRosales-Corral, Sergio-
Autor(es): dc.creatorZuccari, Debora Aparecida Pires de Campos-
Autor(es): dc.creatorChuffa, Luiz Gustavo de Almeida-
Data de aceite: dc.date.accessioned2022-08-04T22:09:42Z-
Data de disponibilização: dc.date.available2022-08-04T22:09:42Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-08-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.lfs.2021.119597-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221758-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221758-
Descrição: dc.descriptionThis brief review describes the association of the endogenous pineal melatonin rhythm with the metabolic flux of solid tumors, particularly breast cancer. It also summarizes new information on the potential mechanisms by which endogenously-produced or exogenously-administered melatonin impacts the metabolic phenotype of cancer cells. The evidence indicates that solid tumors may redirect their metabolic phenotype from the pathological Warburg-type metabolism during the day to the healthier mitochondrial oxidative phosphorylation on a nightly basis. Thus, they function as cancer cells only during the day and as healthier cells at night, that is, they are only part-time cancerous. This switch to oxidative phosphorylation at night causes cancer cells to exhibit a reduced tumor phenotype and less likely to rapidly proliferate or to become invasive or metastatic. Also discussed is the likelihood that some solid tumors are especially aggressive during the day and much less so at night due to the nocturnal rise in melatonin which determines their metabolic state. We further propose that when melatonin is used/tested in clinical trials, a specific treatment paradigm be used that is consistent with the temporal metabolic changes in tumor metabolism. Finally, it seems likely that the concurrent use of melatonin in combination with conventional chemotherapies also would improve cancer treatment outcomes.-
Descrição: dc.descriptionDepartment of Cell Systems and Anatomy UT Health San Antonio-
Descrição: dc.descriptionDepartamento de Morfologia y Biologia Celular Facultad de Medicina-
Descrição: dc.descriptionCentro de Investigacion Biomedica de Occidente Instituto Mexicano del Seguro Social-
Descrição: dc.descriptionFaculdade de Medicina de Sao Jose do Rio Preto Laboratorio de Investigacao Molecular do Cancer-
Descrição: dc.descriptionDepartamento de Biologia Estrutural e Funcional Instituto de Biociencias-
Idioma: dc.languageen-
Relação: dc.relationLife Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectHypoxia inducible factor-
Palavras-chave: dc.subjectMitochondria-
Palavras-chave: dc.subjectOxidative phosphorylation-
Palavras-chave: dc.subjectPyruvate dehydrogenase-
Palavras-chave: dc.subjectPyruvate dehydrogenase kinase-
Palavras-chave: dc.subjectWarburg metabolism-
Título: dc.titlePart-time cancers and role of melatonin in determining their metabolic phenotype-
Aparece nas coleções:Repositório Institucional - Unesp

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