Application of botryosphaeran as a carbon black adherent on a glassy carbon electrode for the electrochemical determination of cyclobenzaprine

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Autor(es): dc.contributorUniversidade Estadual de Londrina (UEL)-
Autor(es): dc.contributorManchester Metropolitan University-
Autor(es): dc.contributorUniversidade do Estado de São Paulo-
Autor(es): dc.contributorCâmpus Londrina-
Autor(es): dc.creatorScremin, Jessica-
Autor(es): dc.creatorOlean-Oliveira, André-
Autor(es): dc.creatorSalamanca-Neto, Carlos A.R.-
Autor(es): dc.creatorCeravolo, Graziela S.-
Autor(es): dc.creatorDekker, Robert F.H.-
Autor(es): dc.creatorBarbosa-Dekker, Aneli M.-
Autor(es): dc.creatorBanks, Craig E.-
Autor(es): dc.creatorTeixeira, Marcos F.S.-
Autor(es): dc.creatorSartori, Elen R.-
Data de aceite: dc.date.accessioned2022-08-04T22:09:26Z-
Data de disponibilização: dc.date.available2022-08-04T22:09:26Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2021-05-20-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1016/j.electacta.2021.138176-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221706-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221706-
Descrição: dc.descriptionThe present work describes the performance of a new voltammetric sensor based on the modification of glassy carbon electrodes (GCE) with carbon black (CB) and botryosphaeran (BOT) (CB-BOT/GCE) for the electroanalytical determination of cyclobenzaprine. BOT is a fungal exocellular (1→3)(1→6)-β-ᴅ-glucan, which was used to improve the adherence of CB onto the surface of GCE. The electrochemical characterisation was performed by electrochemical impedance spectroscopy which showed an improvement in the transfer of electrons on the surface of the sensor developed in relation to the unmodified (bare) GCE. The voltammetric behaviour of cyclobenzaprine was studied using bare GCE, BOT/GCE, CB/GCE, and CB-BOT/GCE. All electrodes presented an oxidation peak (+ 1.0 V) for cyclobenzaprine, while the cyclobenzaprine peak intensity on CB-BOT/GCE was found to be 480% higher than the bare GCE. Through employing square-wave voltammetry, the analytical curve was found to be linear over the concentration range of 2.0 to 20.6 μmol L−1 (in 0.1 mol L−1 NaCl solution) with a detection limit (based on 3-sigma) of 0.63 μmol L−1. The developed electrochemical sensor exhibited excellent sensitivity and selectivity and was successfully applied for the voltammetric determination of cyclobenzaprine in pharmaceutical, biological, and environmental samples for the first time using the CB-BOT/GCE electrochemical sensing platform.-
Descrição: dc.descriptionDepartamento de Química Centro de Ciências Exatas Universidade Estadual de Londrina, Rodovia Celso Garcia Cid, 445 Km 380-
Descrição: dc.descriptionFaculty of Science and Engineering Manchester Metropolitan University, Chester Street-
Descrição: dc.descriptionDepartamento de Química e Bioquímica Escola de Ciência e Tecnologia Universidade do Estado de São Paulo-
Descrição: dc.descriptionPrograma de Pós-Graduação em Ciências Fisiológicas Departamento de Ciências Fisiológicas Centro de Ciências Biológicas Universidade Estadual de Londrina-
Descrição: dc.descriptionBeta-Glucan Produtos Farmoquímicos EIRELI UTFPR Câmpus Londrina, Lote 24A, Bloco Zircônia, Avenida João Miguel Caram 731-
Idioma: dc.languageen-
Relação: dc.relationElectrochimica Acta-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCarbon black-
Palavras-chave: dc.subjectCyclobenzaprine-
Palavras-chave: dc.subjectFungal (1→3)(1→6)-β-ᴅ-glucan-
Palavras-chave: dc.subjectModified glassy carbon electrode-
Palavras-chave: dc.subjectSerum and environment samples-
Título: dc.titleApplication of botryosphaeran as a carbon black adherent on a glassy carbon electrode for the electrochemical determination of cyclobenzaprine-
Tipo de arquivo: dc.typelivro digital-
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