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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | LAGEPP-UMR 5007 | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
Autor(es): dc.contributor | University of Lyon | - |
Autor(es): dc.creator | Vega-Chacón, Jaime [UNESP] | - |
Autor(es): dc.creator | Tarhini, Mohamad | - |
Autor(es): dc.creator | Lebaz, Noureddine | - |
Autor(es): dc.creator | Jafelicci, Miguel [UNESP] | - |
Autor(es): dc.creator | Zine, Nadia | - |
Autor(es): dc.creator | Errachid, Abdelhamid | - |
Autor(es): dc.creator | Elaissari, Abdelhamid | - |
Data de aceite: dc.date.accessioned | 2022-08-04T22:09:05Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T22:09:05Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2020-09-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1007/s42250-020-00138-3 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/221595 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/221595 | - |
Descrição: dc.description | Purpose: Hybrid nanoparticles are an interesting type of particles currently employed in nanomedicine. They can combine the therapeutic and diagnostic functions of their components into one single nanosystem and therefore, can be tweaked according to their applications and desired results. The purpose of this work is to develop an easily tuned nano-system of bovine serum albumin-silica hybrid nanoparticles. Methods: BSA nanoparticles were prepared by nanoprecipitation process using water as the solvent phase and ethanol as the non-solvent. Silica was produced through a sol–gel process and deposited inside the BSA nanoparticles via template deposition. The effect of initial concentrations of raw materials on the structure and colloidal properties of the system was evaluated using FTIR, TGA, TEM, and zeta potential measurements. Results: A hybrid structure of BSA-silica was obtained. The results suggest that the particles size, isoelectric point and silica content of the hybrid nanoparticles can be easily tuned by controlling adequately the concentration of TEOS and ammonia. Conclusion: Our method can be considered as a novel approach for hybrid nanoparticle synthesis. To our knowledge, we report for the first time the synthesis of silica-BSA hybrid particles with a non-core–shell structure. In addition, we proved that that the particles size, isoelectric point and silica content of the hybrid nanoparticles can be easily tuned by controlling adequately the concentration of TEOS and ammonia. | - |
Descrição: dc.description | Campus France | - |
Descrição: dc.description | H2020 European Research Council | - |
Descrição: dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
Descrição: dc.description | University Lyon University Claude Bernard Lyon-1 CNRS LAGEPP-UMR 5007, 43 Boulevard du 11 Novembre 1918 | - |
Descrição: dc.description | Institute of Chemistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Institute of Analytical Sciences UMR 5280 Claude Bernard Lyon 1 University University of Lyon | - |
Descrição: dc.description | Institute of Chemistry São Paulo State University (UNESP) | - |
Descrição: dc.description | Campus France: 57129895 | - |
Descrição: dc.description | H2020 European Research Council: 643694 | - |
Descrição: dc.description | CAPES: 88881.132878/2016-01 | - |
Formato: dc.format | 793-801 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Chemistry Africa | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | BSA | - |
Palavras-chave: dc.subject | Characterization | - |
Palavras-chave: dc.subject | Hybrid nanoparticles | - |
Palavras-chave: dc.subject | Silica | - |
Título: dc.title | Protein-Silica Hybrid Submicron Particles: Preparation and Characterization | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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