Vitamin D3 suppresses the early stages of chemically induced hepatocarcinogenesis in rats: a dose-response analysis

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorTablas, Mariana B. [UNESP]-
Autor(es): dc.creatorGoto, Renata L. [UNESP]-
Autor(es): dc.creatorCaetano, Brunno F. R. [UNESP]-
Autor(es): dc.creatordos Santos, Sérgio A. A. [UNESP]-
Autor(es): dc.creatorBarbisan, Luis F. [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:08:29Z-
Data de disponibilização: dc.date.available2022-08-04T22:08:29Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2018-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1186/s41110-018-0065-2-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221419-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221419-
Descrição: dc.descriptionBackground: The aim of this study was to investigate dose-response effects of vitamin D3 (VD3) supplementation on the early stages of diethylnitrosamine (DEN) and carbon tetrachloride (CCl4)-induced hepatocarcinogenesis in rats. Methods: The animals were randomly allocated into six experimental groups (10 rats each) treated as follows: group 1: no treatment; groups 2–6: single intraperitoneal injection of N-diethylnitrosamine; groups 2–6: intragastric CCl4; groups 3–6: intragastric VD3 at 10,000, 20,000, 40,000, and 60,000 IU/kg b.w., respectively. Results: Serum 25-hydroxyvitamin D (25-OHD) levels in the VD3-supplemented groups were significantly higher than those in the control groups (G1 and G2, p < 0.001). Serum levels of phosphate were higher in the groups supplemented with VD3 at 10,000 and 60,000 IU/kg (G3 and G6, p < 0.005). VD3 higher doses reduced cell proliferation and the number of larger placental glutathione S-transferase (GST-P)-positive hepatocellular preneoplastic lesions. Neither the DEN/CCl4 regimen nor the VD3 supplementation altered vitamin D receptor (VDR) protein expression in the liver. Conclusion: The results indicate that high-dose VD3 supplementation reduced the development of DEN/CCl4-induced preneoplastic lesions in the liver.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionDepartment of Morphology Institute of Biosciences Sao Paulo State University, Rua Prof. Dr. Antônio Celso Wagner Zanin s/n-
Descrição: dc.descriptionDepartment of Morphology Institute of Biosciences Sao Paulo State University, Rua Prof. Dr. Antônio Celso Wagner Zanin s/n-
Descrição: dc.descriptionFAPESP: 2012/03628-8-
Descrição: dc.descriptionFAPESP: 2012/03964-8-
Descrição: dc.descriptionCAPES: DS 2013-2016-
Idioma: dc.languageen-
Relação: dc.relationNutrire-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectCell proliferation-
Palavras-chave: dc.subjectHepatocarcinogenesis-
Palavras-chave: dc.subjectPreneoplastic lesions-
Palavras-chave: dc.subjectVitamin D-
Título: dc.titleVitamin D3 suppresses the early stages of chemically induced hepatocarcinogenesis in rats: a dose-response analysis-
Tipo de arquivo: dc.typelivro digital-
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