The experimental chemical hardness in the interaction between β-tubulin and epothilone B

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidad Industrial de Santander-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorCorzo, S. P.-
Autor(es): dc.creatorBueno, P. R. [UNESP]-
Autor(es): dc.creatorMiranda, D. A.-
Data de aceite: dc.date.accessioned2022-08-04T22:08:28Z-
Data de disponibilização: dc.date.available2022-08-04T22:08:28Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2019-11-20-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1088/1742-6596/1403/1/012016-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221412-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221412-
Descrição: dc.descriptionWe showed the use of the experimental chemical hardness in the analysis of the interaction between β-tubulin and epothilone B. The interaction is analyzed by exposing the Epothilone B to a sensor based on an organic self-assembled monolayer functionalized with Beta tubulin. The proposed methodology is nondestructive and label-free. It allows us to compare the interaction between Beta-tubulin and different concentrations of the pharmacological molecule, i.e., epothilone B. The interaction is analyzed by the experimental hardness obtained according to the Miranda-Bueno methodology. We observed a linear behavior between the logarithm of the chemical hardness and the logarithm of epothilone B concentration. The results suggest the experimental chemical hardness can be used to compare the interaction of β-tubulin with epothilone B and with other pharmacological molecules.-
Descrição: dc.descriptionUniversidad Industrial de Santander-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Descrição: dc.descriptionUniversidade Estadual Paulista-
Idioma: dc.languageen-
Relação: dc.relationJournal of Physics: Conference Series-
???dc.source???: dc.sourceScopus-
Título: dc.titleThe experimental chemical hardness in the interaction between β-tubulin and epothilone B-
Aparece nas coleções:Repositório Institucional - Unesp

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