Effect of a constant rate infusion of remifentanil hydrochloride on left ventricular systolic and diastolic function in propofol-anesthetized dogs

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorMarques, Marcel G. [UNESP]-
Autor(es): dc.creatorCancelli, Carlos H. B. [UNESP]-
Autor(es): dc.creatorFernandes, Carollina M. S. [UNESP]-
Autor(es): dc.creatorGames, Bruna M. M. [UNESP]-
Autor(es): dc.creatorFloriano, Beatriz P. [UNESP]-
Autor(es): dc.creatorPerri, Silvia H. V. [UNESP]-
Autor(es): dc.creatorSousa, Marlos G. [UNESP]-
Autor(es): dc.creatorFerreira, Wagner L. [UNESP]-
Autor(es): dc.creatorSantos, Paulo S. P. [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:07:48Z-
Data de disponibilização: dc.date.available2022-08-04T22:07:48Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2018-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.2460/ajvr.79.12.1253-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221212-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221212-
Descrição: dc.descriptionOBJECTIVE To assess the effects of a constant rate infusion (CRI) of remifentanil hydrochloride on left ventricular systolic and diastolic function in healthy propofol-anesthetized dogs. ANIMALS 6 healthy Beagles. PROCEDURES Each dog underwent 2 experimental treatments separated by a 7-day interval. In 1 treatment, anesthesia was induced with propofol and maintained with a CRI of propofol (0.6 mg/kg/min); dogs also received a CRI of saline (0.9% NaCl) solution. In the other treatment, anesthesia was similarly induced and maintained with propofol; dogs also received a CRI of remifentanil (0.3 µg/kg/min). Doppler echocardiographic and hemodynamic variables of interest were determined at baseline (before anesthesia) and at 20, 40, and 60 minutes following the simultaneous start of the 2 CRIs of each treatment; all CRIs were administrated for 60 minutes. RESULTS For the 2 treatments, end-diastolic and end-systolic volume indices did not differ from baseline or at any time point. Peak tissue Doppler-derived mitral annulus systolic velocity decreased from baseline with both treatments; however, no differences were found between treatments at any time point. Mean arterial blood pressure decreased similarly with both treatments. Heart rate and Doppler-determined cardiac index decreased significantly with the propofol-remifentanil treatment, compared with findings for the propofol-saline solution treatment. For the propofol-remifentanil treatment, the ratio of peak velocity flow in early diastole to that in late diastole remained > 1.80, whereas the ratio of early to late Doppler-derived mitral annulus velocity had a normal relaxation pattern. CONCLUSIONS AND CLINICAL RELEVANCE Results of this study indicated that a CRI of remifentanil administered along with a CRI of propofol does not impair left ventricular systolic and diastolic function in healthy dogs.-
Descrição: dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Animal Clinic Surgery and Reproduction Faculty of Veterinary Medicine São Paulo State University-
Descrição: dc.descriptionDepartment of Animal Clinic Surgery and Reproduction Faculty of Veterinary Medicine São Paulo State University-
Descrição: dc.descriptionFAPESP: 2015/01806-4-
Formato: dc.format1261-1267-
Idioma: dc.languageen-
Relação: dc.relationAmerican Journal of Veterinary Research-
???dc.source???: dc.sourceScopus-
Título: dc.titleEffect of a constant rate infusion of remifentanil hydrochloride on left ventricular systolic and diastolic function in propofol-anesthetized dogs-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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