A phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models

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Autor(es): dc.contributorUniversidade Federal de Minas Gerais (UFMG)-
Autor(es): dc.contributorUniversidade CEUMA (UNICEUMA)-
Autor(es): dc.contributorUniv Estadual de São Paulo-
Autor(es): dc.contributorAlpert Medical School and Brown University-
Autor(es): dc.creatorSá, Nívea P.-
Autor(es): dc.creatorLima, Caroline M-
Autor(es): dc.creatorA Dos Santos, Julliana R.-
Autor(es): dc.creatorCosta, Marliete C.-
Autor(es): dc.creatorDe Barros, Patrícia P.-
Autor(es): dc.creatorJunqueira, Juliana C.-
Autor(es): dc.creatorVaz, Jéssica A.-
Autor(es): dc.creatorOliveira, Renata B.-
Autor(es): dc.creatorFuchs, Beth B.-
Autor(es): dc.creatorMylonakis, Eleftherios-
Autor(es): dc.creatorRosa, Carlos A.-
Autor(es): dc.creatorSantos, Daniel A.-
Autor(es): dc.creatorJohann, Susana-
Data de aceite: dc.date.accessioned2022-08-04T22:07:43Z-
Data de disponibilização: dc.date.available2022-08-04T22:07:43Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2018-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4155/fsoa-2018-0001-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/221179-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/221179-
Descrição: dc.descriptionAim: In this work we test 2-(2-(cyclohexylmethylene)hydrazinyl)-4-phenylthiazole (CHT) against Cryptococcus spp. and Candida albicans. Methods: The ability of CHT to act in biofilm and also to interfere with C. albicans adhesion was evaluated, as well as the efficiency of the CHT in cryptococcosis and candidiasis invertebrate and murine models. Results & conclusion: In the present work we verified that CHT is found to inhibit Cryptococcus and C. albicans affecting biofilm in both and inhibited adhesion of Candida to human buccal cells. When we evaluated in vivo, CHT prolonged survival of Galleria mellonella after infections with Cryptococcusgattii, Cryptococcusneoformans or C. albicans and promoted a reduction in the fungal burden to the organs in the murine models. These results demonstrate CHT therapeutic potential.-
Descrição: dc.descriptionDepartment of Microbiology Institute of Biological Sciences Universidade Federal de Minas Gerais-
Descrição: dc.descriptionPostgraduate Program Universidade CEUMA (UNICEUMA)-
Descrição: dc.descriptionDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology Univ Estadual de São Paulo-
Descrição: dc.descriptionDepartment of Pharmaceutical Products Faculdade de Farmácia Universidade Federal de Minas Gerais-
Descrição: dc.descriptionDivision of Infectious Diseases Rhode Island Hospital Alpert Medical School and Brown University-
Idioma: dc.languageen-
Relação: dc.relationFuture Science OA-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantifungal-
Palavras-chave: dc.subjectCandida albicans-
Palavras-chave: dc.subjectCryptococcus spp.-
Palavras-chave: dc.subjectGalleria mellonella-
Palavras-chave: dc.subjectmice-
Palavras-chave: dc.subjectthiazole-
Palavras-chave: dc.subjectvirulence-
Título: dc.titleA phenylthiazole derivative demonstrates efficacy on treatment of the cryptococcosis & candidiasis in animal models-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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