Trichoderma asperelloides Spores Downregulate dectin1/2 and TLR2 Receptors of Mice Macrophages and Decrease Candida parapsilosis Phagocytosis Independent of the M1/M2 Polarization

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Autor(es): dc.contributorUniversidade Estadual de Santa Cruz-
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorInstituto Federal do Paraná-
Autor(es): dc.contributorUniversidade Federal de Belo Horizonte-
Autor(es): dc.contributorFundação Oswaldo Cruz-
Autor(es): dc.contributorUniversidade de Uberaba-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatordos Santos, Andréa G.-
Autor(es): dc.creatorMendes, Érica A.-
Autor(es): dc.creatorde Oliveira, Rafael P.-
Autor(es): dc.creatorFaria, Ana M.C.-
Autor(es): dc.creatorde Sousa, Aurizangela O.-
Autor(es): dc.creatorPirovani, Carlos P.-
Autor(es): dc.creatorde Araújo, Fernanda F.-
Autor(es): dc.creatorde Carvalho, Andréa T.-
Autor(es): dc.creatorCosta, Marliete Carvalho-
Autor(es): dc.creatorSantos, Daniel Assis-
Autor(es): dc.creatorMontoya, Quimi V. [UNESP]-
Autor(es): dc.creatorRodrigues, Andre [UNESP]-
Autor(es): dc.creatordos Santos, Jane L.-
Data de aceite: dc.date.accessioned2022-08-04T22:06:40Z-
Data de disponibilização: dc.date.available2022-08-04T22:06:40Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2017-09-07-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.3389/fmicb.2017.01681-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/220919-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/220919-
Descrição: dc.descriptionThe intensive use of pesticides to control pests in agriculture has promoted several issues relating to environment. As chemical pesticides remain controversial, biocontrol agents originating from fungi could be an alternative. Among them, we highlight biocontrol agents derived from the fungi genus Trichoderma, which have been documented in limiting the growth of other phytopathogenic fungus in the roots and leaves of several plant species. An important member of this genus is Trichoderma asperelloides, whose biocontrol agents have been used to promote plant growth while also treating soil diseases caused by microorganisms in both greenhouses and outdoor crops. To evaluate the safety of fungal biological agents for human health, tests to detect potentially adverse effects, such as allergenicity, toxicity, infectivity and pathogenicity, are crucial. In addition, identifying possible immunomodulating properties of fungal biocontrol agents merits further investigation. Thus, the aim of this study was to evaluate the effects of T. asperelloides spores in the internalization of Candida parapsilosis yeast by mice phagocytes, in order to elucidate the cellular and molecular mechanism of this interaction, as a model to understand possible in vivo effects of this fungus. For this, mice were exposed to a fungal spore suspension through-intraperitoneal injection, euthanized and cells from the peripheral blood and peritoneal cavity were collected for functional, quantitative and phenotypic analysis, throughout analysis of membrane receptors gene expression, phagocytosis ability and cells immunophenotyping M1 (CCR7 and CD86) and M2 (CCR2 and CD206). Our analyses showed that phagocytes exposed to fungal spores had reduced phagocytic capacity, as well as a decrease in the quantity of neutrophils and monocytes in the peripheral blood and peritoneal cavity. Moreover, macrophages exposed to T. asperelloides spores did not display the phenotypic profile M1/M2, and had reduced expression of pattern recognition receptors, such as TLR2, dectin-1 and dectin-2, all involved in the first line of defense against clinically important yeasts. Our data could infer that T. asperelloides spores may confer susceptibility to infection by C. parapsilosis.-
Descrição: dc.descriptionPrograma de Pós-Graduação em Biologia e Biotecnologia de Microrganismos Universidade Estadual de Santa Cruz-
Descrição: dc.descriptionDepartamento de Microbiologia Instituto de Ciências Biológicas Universidade de São Paulo-
Descrição: dc.descriptionInstituto Federal do Paraná-
Descrição: dc.descriptionDepartamento de Microbiologia Instituto de Ciências Biológicas Universidade Federal de Belo Horizonte-
Descrição: dc.descriptionDepartamento de Ciências Biológicas Universidade Estadual de Santa Cruz-
Descrição: dc.descriptionGrupo Integrado de Pesquisas em Biomarcadores Centro de Pesquisas René Rachou Fundação Oswaldo Cruz-
Descrição: dc.descriptionPrograma de Pós-Graduaçao em Sanidade e Producao Animal nos Trópicos Universidade de Uberaba-
Descrição: dc.descriptionDepartamento de Bioquímica e Microbiologia Instituto de Biociências Universidade Estadual de São Paulo-
Descrição: dc.descriptionDepartamento de Bioquímica e Microbiologia Instituto de Biociências Universidade Estadual de São Paulo-
Idioma: dc.languageen-
Relação: dc.relationFrontiers in Microbiology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiocontrol agent-
Palavras-chave: dc.subjectCandida parapsilosis-
Palavras-chave: dc.subjectConidia-
Palavras-chave: dc.subjectPhagocytosis-
Palavras-chave: dc.subjectPRRs-
Título: dc.titleTrichoderma asperelloides Spores Downregulate dectin1/2 and TLR2 Receptors of Mice Macrophages and Decrease Candida parapsilosis Phagocytosis Independent of the M1/M2 Polarization-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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