Effects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorUniversity of Salerno-
Autor(es): dc.contributorUniversity of Messina-
Autor(es): dc.creatorNegri, K. M.S. [UNESP]-
Autor(es): dc.creatorMalafronte, N.-
Autor(es): dc.creatorCerto, G.-
Autor(es): dc.creatorD’Angelo, V.-
Autor(es): dc.creatorRapisarda, A.-
Autor(es): dc.creatorBauab, T. M. [UNESP]-
Autor(es): dc.creatorGermanò, M. P.-
Data de aceite: dc.date.accessioned2022-08-04T22:06:27Z-
Data de disponibilização: dc.date.available2022-08-04T22:06:27Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2017-04-30-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/220857-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/220857-
Descrição: dc.descriptionAstronium urundeuva (Fr. All.) Engl. (aroeira-do-sertão) (Anacardiaceae) is an arboreal species typical of northeast brazilian savanna popularly used for its anti-inflammatory, antimicrobial, anti-ulcerogenic and healing properties. In this study the effects of A. urundeuva on in vivo angiogenesis are evaluated. Stem bark (AUS) and leaves (AUL) extracts (EtOH 70%) are investigated on zebrafish embryos and chick chorioallantoic membrane (CAM). Results of the biological screening show that AUS extracts induce a weak anti-angiogenic response in both experimental models. Conversely, AUL extracts at 25 and 50 μg/mL enhance vessel formation in zebrafish embryos submitted to the endogenous alkaline phosphatase (EAP) assay. Moreover, an increased blood vessel development and an higher level of total hemoglobin content is observed in the CAMs exposed to AUL at 80 μg/egg as compared to control. The proangiogenic effects of AUL in two in vivo models suggest its potential use as a source of new therapeutic agents able to modulate angiogenesis.-
Descrição: dc.descriptionDepartment of Biological Sciences Univ Estadual Paulista-
Descrição: dc.descriptionDepartment of Pharmacy University of Salerno, Via Giovanni Paolo II 132-
Descrição: dc.descriptionDepartment of Chemical Biological Pharmaceutical and Environmental Sciences University of Messina-
Descrição: dc.descriptionDepartment of Biological Sciences Univ Estadual Paulista-
Formato: dc.format46-54-
Idioma: dc.languageen-
Relação: dc.relationPharmacologyonline-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAngiogenesis-
Palavras-chave: dc.subjectAstronium urundeuva-
Palavras-chave: dc.subjectChick chorioallantoic membrane-
Palavras-chave: dc.subjectEndogenous alkaline phosphatase staining-
Palavras-chave: dc.subjectHaemoglobin-
Palavras-chave: dc.subjectZebrafish-
Título: dc.titleEffects on in vivo angiogenesis of extracts from astronium Urundeuva (FR. ALL.) Engl. (Anacardiaceae)-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.