Effect of doxycycline in gel form on bone regeneration: Histomorphometric and tomographic study in rat calvaria

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorFederal University of Alfenas-
Autor(es): dc.contributorSão Paulo Estadual University-
Autor(es): dc.creatorSilva, Amanda C.-
Autor(es): dc.creatorOliveira, Marina R.-
Autor(es): dc.creatorAmaral, Lysandro F. A.-
Autor(es): dc.creatorFerreira, Sabrina-
Autor(es): dc.creatorGarcia, Idelmo R.-
Autor(es): dc.creatorMariano, Ronaldo C.-
Data de aceite: dc.date.accessioned2022-08-04T22:05:14Z-
Data de disponibilização: dc.date.available2022-08-04T22:05:14Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2016-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1902/jop.2015.150343-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/220532-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/220532-
Descrição: dc.descriptionBackground: This study aims to investigate the effects of the local application of doxycycline in the form of natrosolbased gel on bone regeneration by examining critical defects in rat calvaria. Methods: Twenty-four rats were randomly divided into three groups with eight animals each, according to the treatment received: BC (untreated, filled with blood clot), NAT (natrosol gel alone), and DOX (10% doxycycline gel). Four animals from each group were euthanized at 4 and 8 weeks postoperatively. In tomographic analysis, mean density in the region of the defect was calculated as a percentage relative to the native bone density. In histomorphometric analysis, the newly formed bone area was calculated as a percentage of the total area. The values obtained underwent analysis of variance and Tukey testing (P <0.05). Results: The mean percentage of tomographic density in the region of the defect at the end of 8 weeks was higher for DOX (44.37%), and statistical differences in this period were observed between DOX and NAT (33.10%) and DOX and BC (32.43%). Regarding new bone formation, at the end of 8 weeks, DOX (61.11%) also had the highest mean bone formation, and statistical differences were observed between DOX and NAT (34.61%) and DOX and BC (23.11%). Conclusion: It was observed that 10% doxycycline gel had a good effect on bone regeneration regarding the filling of critical defects in rat calvaria.-
Descrição: dc.descriptionDepartment of Clinic and Surgery Federal University of Alfenas, Rua das Perdizes, 186 Jardim São Paulo-
Descrição: dc.descriptionDepartment of Diagnostics and Surgery São Paulo Estadual University-
Descrição: dc.descriptionDepartment of Surgery and Clinical Integrated São Paulo Estadual University-
Formato: dc.format74-82-
Idioma: dc.languageen-
Relação: dc.relationJournal of Periodontology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectBiocompatible materials-
Palavras-chave: dc.subjectBone regeneration-
Palavras-chave: dc.subjectCone-beam computed tomography-
Palavras-chave: dc.subjectDoxycycline-
Palavras-chave: dc.subjectTissue engineering-
Palavras-chave: dc.subjectTissue scaffolds-
Título: dc.titleEffect of doxycycline in gel form on bone regeneration: Histomorphometric and tomographic study in rat calvaria-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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