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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | Federal University of Alfenas | - |
Autor(es): dc.contributor | São Paulo Estadual University | - |
Autor(es): dc.creator | Silva, Amanda C. | - |
Autor(es): dc.creator | Oliveira, Marina R. | - |
Autor(es): dc.creator | Amaral, Lysandro F. A. | - |
Autor(es): dc.creator | Ferreira, Sabrina | - |
Autor(es): dc.creator | Garcia, Idelmo R. | - |
Autor(es): dc.creator | Mariano, Ronaldo C. | - |
Data de aceite: dc.date.accessioned | 2022-08-04T22:05:14Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T22:05:14Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2016-01-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1902/jop.2015.150343 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/220532 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/220532 | - |
Descrição: dc.description | Background: This study aims to investigate the effects of the local application of doxycycline in the form of natrosolbased gel on bone regeneration by examining critical defects in rat calvaria. Methods: Twenty-four rats were randomly divided into three groups with eight animals each, according to the treatment received: BC (untreated, filled with blood clot), NAT (natrosol gel alone), and DOX (10% doxycycline gel). Four animals from each group were euthanized at 4 and 8 weeks postoperatively. In tomographic analysis, mean density in the region of the defect was calculated as a percentage relative to the native bone density. In histomorphometric analysis, the newly formed bone area was calculated as a percentage of the total area. The values obtained underwent analysis of variance and Tukey testing (P <0.05). Results: The mean percentage of tomographic density in the region of the defect at the end of 8 weeks was higher for DOX (44.37%), and statistical differences in this period were observed between DOX and NAT (33.10%) and DOX and BC (32.43%). Regarding new bone formation, at the end of 8 weeks, DOX (61.11%) also had the highest mean bone formation, and statistical differences were observed between DOX and NAT (34.61%) and DOX and BC (23.11%). Conclusion: It was observed that 10% doxycycline gel had a good effect on bone regeneration regarding the filling of critical defects in rat calvaria. | - |
Descrição: dc.description | Department of Clinic and Surgery Federal University of Alfenas, Rua das Perdizes, 186 Jardim São Paulo | - |
Descrição: dc.description | Department of Diagnostics and Surgery São Paulo Estadual University | - |
Descrição: dc.description | Department of Surgery and Clinical Integrated São Paulo Estadual University | - |
Formato: dc.format | 74-82 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of Periodontology | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | Biocompatible materials | - |
Palavras-chave: dc.subject | Bone regeneration | - |
Palavras-chave: dc.subject | Cone-beam computed tomography | - |
Palavras-chave: dc.subject | Doxycycline | - |
Palavras-chave: dc.subject | Tissue engineering | - |
Palavras-chave: dc.subject | Tissue scaffolds | - |
Título: dc.title | Effect of doxycycline in gel form on bone regeneration: Histomorphometric and tomographic study in rat calvaria | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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