Mitochondrial genome instability in colorectal adenoma and adenocarcinoma

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade de São Paulo (USP)-
Autor(es): dc.contributorRegional Blood Center of Ribeirão Preto-
Autor(es): dc.creatorde Araujo, Luiza F.-
Autor(es): dc.creatorFonseca, Aline S.-
Autor(es): dc.creatorMuys, Bruna R-
Autor(es): dc.creatorPlaça, Jessica R.-
Autor(es): dc.creatorBueno, Rafaela B. L.-
Autor(es): dc.creatorLorenzi, Julio C. C.-
Autor(es): dc.creatorSantos, Anemari R. D.-
Autor(es): dc.creatorMolfetta, Greice A.-
Autor(es): dc.creatorZanette, Dalila L.-
Autor(es): dc.creatorSouza, Jorge E. S.-
Autor(es): dc.creatorValente, Valeria-
Autor(es): dc.creatorSilva, Wilson A.-
Data de aceite: dc.date.accessioned2022-08-04T22:05:09Z-
Data de disponibilização: dc.date.available2022-08-04T22:05:09Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2015-11-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1007/s13277-015-3640-7-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/220511-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/220511-
Descrição: dc.descriptionMitochondrial dysfunction is regarded as a hallmark of cancer progression. In the current study, we evaluated mitochondrial genome instability and copy number in colorectal cancer using Next Generation Sequencing approach and qPCR, respectively. The results revealed higher levels of heteroplasmy and depletion of the relative mtDNA copy number in colorectal adenocarcinoma. Adenocarcinoma samples also presented an increased number of mutations in nuclear genes encoding proteins which functions are related with mitochondria fusion, fission and localization. Moreover, we found a set of mitochondrial and nuclear genes, which cooperate in the same mitochondrial function simultaneously mutated in adenocarcinoma. In summary, these results support an important role for mitochondrial function and genomic instability in colorectal tumorigenesis.-
Descrição: dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
Descrição: dc.descriptionDepartment of Genetics Ribeirão Preto Medical School University of São Paulo-
Descrição: dc.descriptionCenter for Cell-Based Therapy (CEPID/FAPESP); National institute of Science and Technology in Stem Cell and Cell Therapy (INCTC/CNPq) Regional Blood Center of Ribeirão Preto-
Descrição: dc.descriptionCenter for Medical Genomics (HCFMRP/USP) Center for Integrative Systems Biology (CISBi – NAP/USP)-
Descrição: dc.descriptionDepartment of Clinical Analysis University of São Paulo State-
Descrição: dc.descriptionFAPESP: 2008/57877-3-
Descrição: dc.descriptionFAPESP: 2013/08135-2-
Descrição: dc.descriptionFAPESP: 573754/2008-0-
Formato: dc.format8869-8879-
Idioma: dc.languageen-
Relação: dc.relationTumor Biology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectColorectal cancer-
Palavras-chave: dc.subjectGenome instability-
Palavras-chave: dc.subjectHeteroplasmy-
Palavras-chave: dc.subjectMitochondrial genome-
Título: dc.titleMitochondrial genome instability in colorectal adenoma and adenocarcinoma-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.