Antiviral activity of an aqueous extract from the red alga Laurencia obtusa against influenza A and B viruses

Registro completo de metadados
MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorLaboratorio de Cultivo de Células. Instituto de Medicina Tropical ¨Pedro Kourí¨-
Autor(es): dc.contributorCentro de Bioproductos Marinos (CEBIMAR)-
Autor(es): dc.contributorUniversidad de La Habana-
Autor(es): dc.creatorPérez-Riverol, Amilcar [UNESP]-
Autor(es): dc.creatorPiñón Ramos, Alexander-
Autor(es): dc.creatorMorier Díaz, Luis Francisco-
Autor(es): dc.creatorTorres López, Yuneysi-
Autor(es): dc.creatorMendoza Llanes, Dianeya-
Autor(es): dc.creatordel Barrio Alonso, Gloria-
Data de aceite: dc.date.accessioned2022-08-04T22:04:25Z-
Data de disponibilização: dc.date.available2022-08-04T22:04:25Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2014-01-01-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/220285-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/220285-
Descrição: dc.descriptionIntroduction: antiviral therapy against infections caused by influenza viruses is based on the use of inhibitors of M2 protein and neuraminidase (NA). However, the emergence of seasonal strains resistant to both drug groups has led to the search for new anti-influenza medications. Extracts from algae may be used as a source of compounds, considering the diversity of metabolites described for these organisms. Objective: evaluate the in vitro antiviral activity of an aqueous extract from the red alga Laurencia obtusa against influenza A (H1N1), A (H3N2) and B viruses. Methods: cytotoxicity was evaluated in MDCK cells by cell viability estimation in the presence of growing concentrations of the extract. The effects over viral replication were quantified by determining hemagglutinin (HA) levels and inhibition of the cytopathic effect (CPE). The selective index (SI) was estimated by SI=CC50/CE50 Results: the aqueous extract of Laurencia obtusa showed in vitro antiviral activity against influenza B, A (H3N2) and A (H1N1) viruses with SI values of 7.73, 11.79 and 12.95, respectively. Conclusions: Laurencia obtusa inhibits the replication of influenza viruses, a fact of great clinical importance. Secondary assays to characterize the biological activity and molecular composition of the extract may lead to the development of novel antiviral compounds. The present paper is the first report on the inhibitory activity of this macroalga species against influenza viruses.-
Descrição: dc.descriptionLaboratorio de Biología Molecular. Dpto de Biología Instituto de Biociencias Universidad Estadual Paulista Júlio de Mesquita Filho-
Descrição: dc.descriptionLaboratorio Nacional de Referencia de Virus Influenza Departamento de Virología Laboratorio de Cultivo de Células. Instituto de Medicina Tropical ¨Pedro Kourí¨-
Descrição: dc.descriptionCentro de Bioproductos Marinos (CEBIMAR)-
Descrição: dc.descriptionGrupo de Antivirales Naturales Dpto. de Microbiología y Virología Universidad de La Habana-
Descrição: dc.descriptionLaboratorio de Biología Molecular. Dpto de Biología Instituto de Biociencias Universidad Estadual Paulista Júlio de Mesquita Filho-
Formato: dc.format273-285-
Idioma: dc.languagees-
Relação: dc.relationRevista Cubana de Medicina Tropical-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAlgae-
Palavras-chave: dc.subjectAntiviral-
Palavras-chave: dc.subjectInfluenza-
Palavras-chave: dc.subjectLaurencia obtusa-
Palavras-chave: dc.subjectNatural extracts-
Título: dc.titleAntiviral activity of an aqueous extract from the red alga Laurencia obtusa against influenza A and B viruses-
Título: dc.titleActividad antiviral de un extracto acuoso del alga roja Laurencia obtusa frente a virus influenza A y B-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

Não existem arquivos associados a este item.