Impact of age on viral kinetics of peginterferon alfa-2a/ribavirin in chronic hepatitis C: Final analysis from the PROPHESYS cohort

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Autor(es): dc.contributorUniversity of Chicago Medical Center-
Autor(es): dc.contributorClinical Hospital Dr. I. Cantacuzino-
Autor(es): dc.contributorMatei Bals Infectious Diseases Institute-
Autor(es): dc.contributorUnità Operativa Epatologia Ed Ecografia Interventistica Ospedale Gragnano-
Autor(es): dc.contributorClinic for Infectious Disease, Clinical Center Serbia-
Autor(es): dc.contributorDivisione di Medicina Interna, Ospedale Regina Margherita-
Autor(es): dc.contributorRoyal Free and University College School of Medicine-
Autor(es): dc.contributor2nd Department of Medicine, Semmelweis University-
Autor(es): dc.contributorHôpital Beaujon-
Autor(es): dc.contributorAzienda Ospedaliero-Universitaria di Parma-
Autor(es): dc.contributorHigh Desert Gastroenterology Suite B-
Autor(es): dc.contributorBotucatu School of Medicine-
Autor(es): dc.contributorDivisione di Medicina, Ospedale Elena d'Aosta-
Autor(es): dc.contributorIST GmbH-
Autor(es): dc.contributorF. Hoffmann-La Roche-
Autor(es): dc.contributorGenentech-
Autor(es): dc.contributorHospital de Clinicas de Porto Alegre-
Autor(es): dc.creatorAronsohn, A.-
Autor(es): dc.creatorAncuta, I.-
Autor(es): dc.creatorCaruntu, F.-
Autor(es): dc.creatorCoppola, C.-
Autor(es): dc.creatorDelic, D.-
Autor(es): dc.creatorDigiacomo, A.-
Autor(es): dc.creatorDusheiko, G. M.-
Autor(es): dc.creatorLengyel, G.-
Autor(es): dc.creatorMarcellin, P.-
Autor(es): dc.creatorOrlandini, A.-
Autor(es): dc.creatorPruthi, J.-
Autor(es): dc.creatorSilva, G. F.-
Autor(es): dc.creatorTallarico, L.-
Autor(es): dc.creatorSchmitz, M.-
Autor(es): dc.creatorTatsch, F.-
Autor(es): dc.creatorKorner, E.-
Autor(es): dc.creatorCheinquer, H.-
Data de aceite: dc.date.accessioned2022-08-04T22:03:56Z-
Data de disponibilização: dc.date.available2022-08-04T22:03:56Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2014-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1111/jvh.12179-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/220127-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/220127-
Descrição: dc.descriptionThe population of patients with chronic hepatitis C viral infection is ageing; however, elderly, hepatitis C-infected patients are understudied and less frequently treated. This subanalysis of data from the multinational PROPHESYS study examined associations between age (≤65 vs >65 years), on-treatment virological response and sustained virological response (SVR) in patients treated with peginterferon alfa-2a (40KD)/ribavirin in accordance with local licences. PROPHESYS comprised three cohorts studied in 19 countries according to country-specific legal and regulatory requirements. This subanalysis includes treatment-naive HCV mono-infected patients assigned to receive peginterferon alfa-2a (40KD)/ribavirin, with 6276 individuals aged ≤65 years and 349 aged >65 years. Rapid virological response (RVR) rates by Week 4 were consistently lower in older genotype (G) 1 (21.6% vs 27.2% in younger patients), G2 (80.7% vs 85.1%) and G3 (60.0% vs 74.2%) patients. SVR rates were significantly lower (29.8% vs 43.0%) and relapse rates significantly higher (43.1% vs 26.7%) in older G1 patients (P = 0.0002 vs ≤65 years). In contrast, SVR and relapse rates were similar in G2 and G3 patients regardless of age. The positive predictive value of RVR for SVR was comparable in older and younger G1 patients (66.7% vs 68.6%, respectively) and higher in older G2 (80.7% vs 75.6%) and G3 (77.8% vs 66.8%) patients. Virological response rates are generally lower in elderly CHC patients, and RVR is a reliable positive predictor of SVR in patients >65 years. © 2013 John Wiley & Sons Ltd.-
Descrição: dc.descriptionUniversity of Chicago Medical Center, 5841 S. Maryland Avenue, Chicago, IL 60637-
Descrição: dc.descriptionClinical Hospital Dr. I. Cantacuzino, Bucharest-
Descrição: dc.descriptionMatei Bals Infectious Diseases Institute, Bucharest-
Descrição: dc.descriptionUnità Operativa Epatologia Ed Ecografia Interventistica Ospedale Gragnano, Naples-
Descrição: dc.descriptionClinic for Infectious Disease, Clinical Center Serbia, Belgrade-
Descrição: dc.descriptionDivisione di Medicina Interna, Ospedale Regina Margherita, Comiso-
Descrição: dc.descriptionRoyal Free and University College School of Medicine, London-
Descrição: dc.description2nd Department of Medicine, Semmelweis University, Budapest-
Descrição: dc.descriptionHôpital Beaujon, Clichy-
Descrição: dc.descriptionAzienda Ospedaliero-Universitaria di Parma, Parma-
Descrição: dc.descriptionHigh Desert Gastroenterology Suite B, Lancaster, CA-
Descrição: dc.descriptionBotucatu School of Medicine, Botucatu-
Descrição: dc.descriptionDivisione di Medicina, Ospedale Elena d'Aosta, Napoli-
Descrição: dc.descriptionIST GmbH, Mannheim-
Descrição: dc.descriptionF. Hoffmann-La Roche, Basel-
Descrição: dc.descriptionGenentech, South San Francisco, CA-
Descrição: dc.descriptionHospital de Clinicas de Porto Alegre, Porto Alegre-
Formato: dc.format377-380-
Idioma: dc.languageen-
Relação: dc.relationJournal of Viral Hepatitis-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectelderly patients-
Palavras-chave: dc.subjecthepatitis C virus-
Palavras-chave: dc.subjectpeginterferon alfa-2a/ribavirin-
Palavras-chave: dc.subjectsustained virological response-
Palavras-chave: dc.subjecttreatment-naive-
Palavras-chave: dc.subjectviral kinetics-
Título: dc.titleImpact of age on viral kinetics of peginterferon alfa-2a/ribavirin in chronic hepatitis C: Final analysis from the PROPHESYS cohort-
Tipo de arquivo: dc.typelivro digital-
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