Rol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio

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MetadadosDescriçãoIdioma
Autor(es): dc.contributorUniversidad de La Frontera-
Autor(es): dc.contributorMedical School-
Autor(es): dc.contributorUniversidad Santo Tomás-
Autor(es): dc.contributorUniversidad Autónoma de Chile-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBustos-Obregón, Eduardo-
Autor(es): dc.creatorPoblete, Daniel-
Autor(es): dc.creatorCatriao, Roberto-
Autor(es): dc.creatordel Sol, Mariano-
Autor(es): dc.creatorFernandes, Fábio Henrique [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:03:48Z-
Data de disponibilização: dc.date.available2022-08-04T22:03:48Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2013-12-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4067/S0717-95022013000400017-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/220083-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/220083-
Descrição: dc.descriptionWe evaluated the sperm parameters such as cauda epididymis weight, sperm count, sperm morphology and sperm DNA stability of adult CF-1 male mice treated daily (oral exposure) with the toxic sodium arsenite (As, 7.0 mg/kg/body weight); Melatonin (Me, 10.0 mg/kg/bw), Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw) and Negative Control (NaCl 0.9%) to assess acute (8.3 days), chronic (33.2 days) and recovery of testicular damage (66.4 days). Arsenic decreases the number of sperm from chronic treatment (33.2 days) and this effect continued until 66.4 days of treatment. The toxic effect of As also altered the morphology of spermatozoa in all treatment periods when compared to the negative control group. However, Metalonin induced protective effects in periods of 33.2 and 66.4 days of treatment. Additionally, the stability of DNA was significantly affected by arsenic in all periods, but the chronic treatment (33.2 days) in the AsMe revealed increased stability compared to the group treated with arsenic only. Melatonin partially protects sperm toxicity caused by Arsenic, especially during periods of 33.2 and 66.4 days.-
Descrição: dc.descriptionUniversidad de La Frontera, Temuco-
Descrição: dc.descriptionUniversity of Chile Medical School, Santiago-
Descrição: dc.descriptionVeterinary School Universidad Santo Tomás-
Descrição: dc.descriptionCentro de Investigación en Ciencias Biomédicas Universidad Autónoma de Chile, Temuco-
Descrição: dc.descriptionSão Paulo State University, Botucatu-
Descrição: dc.descriptionSão Paulo State University, Botucatu-
Formato: dc.format1251-1256-
Idioma: dc.languageen-
Idioma: dc.languagees-
Relação: dc.relationInternational Journal of Morphology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectArsenic-
Palavras-chave: dc.subjectDNA stability-
Palavras-chave: dc.subjectMelatonin-
Palavras-chave: dc.subjectMouse-
Palavras-chave: dc.subjectSperm-
Título: dc.titleRol protector de la melatonina en el daño de espermatozoides de cauda epididimaria en ratón producido por arsenito de sodio-
Título: dc.titleMelatonin protective role in mouse cauda epipidymal spermatozoa damage induced by sodium arsenite-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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