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Metadados | Descrição | Idioma |
---|---|---|
Autor(es): dc.contributor | School of Medicine | - |
Autor(es): dc.contributor | Eduardo de Menezes Hospital | - |
Autor(es): dc.contributor | São Paulo State Secretary of Health | - |
Autor(es): dc.contributor | Evandro Chagas Clinical Research Institute | - |
Autor(es): dc.contributor | São Paulo Federal University | - |
Autor(es): dc.contributor | Vitória Santa Casa School of Medicine | - |
Autor(es): dc.contributor | Partenon Sanatorium Hospital | - |
Autor(es): dc.contributor | Porto Alegre Secretary of Health | - |
Autor(es): dc.contributor | Universidade Estadual de Campinas (UNICAMP) | - |
Autor(es): dc.contributor | Universidade Estadual Paulista (UNESP) | - |
Autor(es): dc.contributor | Ceará State Secretary of Health | - |
Autor(es): dc.contributor | Rio Grande Federal University | - |
Autor(es): dc.creator | Biscione, Fernando Martín | - |
Autor(es): dc.creator | Westin, Mateus Rodrigues | - |
Autor(es): dc.creator | Ribeiro, Karina Mota | - |
Autor(es): dc.creator | Estevam, Denize Lotufo | - |
Autor(es): dc.creator | Cardoso, Sandra Wagner | - |
Autor(es): dc.creator | Tenore, Simone Barros | - |
Autor(es): dc.creator | Neto, Lauro Ferreira Da Silva Pinto | - |
Autor(es): dc.creator | Alencastro, Paulo Ricardo | - |
Autor(es): dc.creator | Suffert, Theodoro Armando | - |
Autor(es): dc.creator | De Moraes, Mônica Jacques | - |
Autor(es): dc.creator | Barbosa, Alexandre Naime [UNESP] | - |
Autor(es): dc.creator | Morejón, Karen Mirna Loro | - |
Autor(es): dc.creator | De Arruda, Érico Antônio Gomes | - |
Autor(es): dc.creator | Silveira, Jussara María | - |
Autor(es): dc.creator | Neto, José Luiz Andrade | - |
Autor(es): dc.creator | Greco, Dirceu Bartolomeu | - |
Autor(es): dc.creator | Tupinambás, Unaí | - |
Data de aceite: dc.date.accessioned | 2022-08-04T22:03:41Z | - |
Data de disponibilização: dc.date.available | 2022-08-04T22:03:41Z | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2022-04-28 | - |
Data de envio: dc.date.issued | 2014-01-01 | - |
Fonte completa do material: dc.identifier | http://dx.doi.org/10.1177/2325957413502542 | - |
Fonte completa do material: dc.identifier | http://hdl.handle.net/11449/220043 | - |
Fonte: dc.identifier.uri | http://educapes.capes.gov.br/handle/11449/220043 | - |
Descrição: dc.description | Introduction: Published data addressing the effectiveness of darunavirritonavir (DRV/r)-based therapy for multiexperienced patients in developing countries are scarce. This study evaluated the 48-week virologic and immunologic effectiveness of salvage therapy based on DRV/r for the treatment of multidrug-experienced HIV-1-infected adults in Brazil. Materials and Methods: A multicenter retrospective cohort study was carried out with multidrug-experienced adults who were on a failing antiretroviral therapy and started a DRV/r-based salvage therapy between 2008 and 2010. The primary effectiveness end point was the proportion of patients with virologic success (plasma HIV-1 RNA <50 copies/mL at week 48). Results: At 48 weeks, 73% of the patients had HIV-RNA <50 copies/mL and a mean increase of 108 CD4 cells/mm3. Higher baseline viral load, lower baseline CD4 count, younger age, and 3 or more DRV/r-associated resistance mutations were significantly predictive of virologic failure. Concomitant use of raltegravir was strongly associated with virologic success. Conclusion: The use of DRV/r-based regimens for salvage therapy is an effective strategy in the clinical care setting of a developing country. © The Author(s) 2013. | - |
Descrição: dc.description | Infectious Diseases and Tropical Medicine Postgraduate Course Minas Gerais Federal University School of Medicine, 190 Professor Alfredo Balena avenue, Minas Gerais, 30130 | - |
Descrição: dc.description | Infectious Diseases Service Eduardo de Menezes Hospital, Belo Horizonte | - |
Descrição: dc.description | Reference Center in STD/Aids São Paulo State Secretary of Health, São Paulo | - |
Descrição: dc.description | Evandro Chagas Clinical Research Institute, Fiocruz, Rio de Janeiro | - |
Descrição: dc.description | Infectious Diseases Outpatient Service São Paulo Federal University, São Paulo | - |
Descrição: dc.description | Internal Medicine Department Vitória Santa Casa School of Medicine, Vitória | - |
Descrição: dc.description | Assistance and Therapy Service Partenon Sanatorium Hospital, Porto Alegre | - |
Descrição: dc.description | Reference Center in STD/Aids Porto Alegre Secretary of Health, Porto Alegre | - |
Descrição: dc.description | Campinas University School of Medicine, Campinas | - |
Descrição: dc.description | Domingos Alves Meira Infectious Diseases Service São Paulo State University, Botucatu | - |
Descrição: dc.description | Infectious Diseases Service Clinics Hospital São Paulo Federal University, São Paulo | - |
Descrição: dc.description | São José Hospital Ceará State Secretary of Health, Fortaleza | - |
Descrição: dc.description | Internal Medicine Department Miguel Riet Corrêa Jr. University Hospital Rio Grande Federal University, Rio Grande | - |
Descrição: dc.description | Paraná Pontifical Catholic University School of Medicine, Paraná | - |
Descrição: dc.description | Domingos Alves Meira Infectious Diseases Service São Paulo State University, Botucatu | - |
Formato: dc.format | 63-68 | - |
Idioma: dc.language | en | - |
Relação: dc.relation | Journal of the International Association of Providers of AIDS Care | - |
???dc.source???: dc.source | Scopus | - |
Palavras-chave: dc.subject | antiretroviral | - |
Palavras-chave: dc.subject | darunavir | - |
Palavras-chave: dc.subject | HIV | - |
Palavras-chave: dc.subject | resistance | - |
Título: dc.title | Virologic and immunologic effectiveness at 48 weeks of darunavir-ritonavir- based regimens in treatment-experienced persons living with HIV-1 infection in clinical practice: A multicenter brazilian cohort | - |
Tipo de arquivo: dc.type | livro digital | - |
Aparece nas coleções: | Repositório Institucional - Unesp |
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