Virologic and immunologic effectiveness at 48 weeks of darunavir-ritonavir- based regimens in treatment-experienced persons living with HIV-1 infection in clinical practice: A multicenter brazilian cohort

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Autor(es): dc.contributorSchool of Medicine-
Autor(es): dc.contributorEduardo de Menezes Hospital-
Autor(es): dc.contributorSão Paulo State Secretary of Health-
Autor(es): dc.contributorEvandro Chagas Clinical Research Institute-
Autor(es): dc.contributorSão Paulo Federal University-
Autor(es): dc.contributorVitória Santa Casa School of Medicine-
Autor(es): dc.contributorPartenon Sanatorium Hospital-
Autor(es): dc.contributorPorto Alegre Secretary of Health-
Autor(es): dc.contributorUniversidade Estadual de Campinas (UNICAMP)-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorCeará State Secretary of Health-
Autor(es): dc.contributorRio Grande Federal University-
Autor(es): dc.creatorBiscione, Fernando Martín-
Autor(es): dc.creatorWestin, Mateus Rodrigues-
Autor(es): dc.creatorRibeiro, Karina Mota-
Autor(es): dc.creatorEstevam, Denize Lotufo-
Autor(es): dc.creatorCardoso, Sandra Wagner-
Autor(es): dc.creatorTenore, Simone Barros-
Autor(es): dc.creatorNeto, Lauro Ferreira Da Silva Pinto-
Autor(es): dc.creatorAlencastro, Paulo Ricardo-
Autor(es): dc.creatorSuffert, Theodoro Armando-
Autor(es): dc.creatorDe Moraes, Mônica Jacques-
Autor(es): dc.creatorBarbosa, Alexandre Naime [UNESP]-
Autor(es): dc.creatorMorejón, Karen Mirna Loro-
Autor(es): dc.creatorDe Arruda, Érico Antônio Gomes-
Autor(es): dc.creatorSilveira, Jussara María-
Autor(es): dc.creatorNeto, José Luiz Andrade-
Autor(es): dc.creatorGreco, Dirceu Bartolomeu-
Autor(es): dc.creatorTupinambás, Unaí-
Data de aceite: dc.date.accessioned2022-08-04T22:03:41Z-
Data de disponibilização: dc.date.available2022-08-04T22:03:41Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2014-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1177/2325957413502542-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/220043-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/220043-
Descrição: dc.descriptionIntroduction: Published data addressing the effectiveness of darunavirritonavir (DRV/r)-based therapy for multiexperienced patients in developing countries are scarce. This study evaluated the 48-week virologic and immunologic effectiveness of salvage therapy based on DRV/r for the treatment of multidrug-experienced HIV-1-infected adults in Brazil. Materials and Methods: A multicenter retrospective cohort study was carried out with multidrug-experienced adults who were on a failing antiretroviral therapy and started a DRV/r-based salvage therapy between 2008 and 2010. The primary effectiveness end point was the proportion of patients with virologic success (plasma HIV-1 RNA <50 copies/mL at week 48). Results: At 48 weeks, 73% of the patients had HIV-RNA <50 copies/mL and a mean increase of 108 CD4 cells/mm3. Higher baseline viral load, lower baseline CD4 count, younger age, and 3 or more DRV/r-associated resistance mutations were significantly predictive of virologic failure. Concomitant use of raltegravir was strongly associated with virologic success. Conclusion: The use of DRV/r-based regimens for salvage therapy is an effective strategy in the clinical care setting of a developing country. © The Author(s) 2013.-
Descrição: dc.descriptionInfectious Diseases and Tropical Medicine Postgraduate Course Minas Gerais Federal University School of Medicine, 190 Professor Alfredo Balena avenue, Minas Gerais, 30130-
Descrição: dc.descriptionInfectious Diseases Service Eduardo de Menezes Hospital, Belo Horizonte-
Descrição: dc.descriptionReference Center in STD/Aids São Paulo State Secretary of Health, São Paulo-
Descrição: dc.descriptionEvandro Chagas Clinical Research Institute, Fiocruz, Rio de Janeiro-
Descrição: dc.descriptionInfectious Diseases Outpatient Service São Paulo Federal University, São Paulo-
Descrição: dc.descriptionInternal Medicine Department Vitória Santa Casa School of Medicine, Vitória-
Descrição: dc.descriptionAssistance and Therapy Service Partenon Sanatorium Hospital, Porto Alegre-
Descrição: dc.descriptionReference Center in STD/Aids Porto Alegre Secretary of Health, Porto Alegre-
Descrição: dc.descriptionCampinas University School of Medicine, Campinas-
Descrição: dc.descriptionDomingos Alves Meira Infectious Diseases Service São Paulo State University, Botucatu-
Descrição: dc.descriptionInfectious Diseases Service Clinics Hospital São Paulo Federal University, São Paulo-
Descrição: dc.descriptionSão José Hospital Ceará State Secretary of Health, Fortaleza-
Descrição: dc.descriptionInternal Medicine Department Miguel Riet Corrêa Jr. University Hospital Rio Grande Federal University, Rio Grande-
Descrição: dc.descriptionParaná Pontifical Catholic University School of Medicine, Paraná-
Descrição: dc.descriptionDomingos Alves Meira Infectious Diseases Service São Paulo State University, Botucatu-
Formato: dc.format63-68-
Idioma: dc.languageen-
Relação: dc.relationJournal of the International Association of Providers of AIDS Care-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectantiretroviral-
Palavras-chave: dc.subjectdarunavir-
Palavras-chave: dc.subjectHIV-
Palavras-chave: dc.subjectresistance-
Título: dc.titleVirologic and immunologic effectiveness at 48 weeks of darunavir-ritonavir- based regimens in treatment-experienced persons living with HIV-1 infection in clinical practice: A multicenter brazilian cohort-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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