Rol protector de la melatonina en el daño de la espermatogénesis en ratón producido por arsenito de sodio

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Autor(es): dc.contributorUniversidad de La Frontera-
Autor(es): dc.contributorUniversity Santo Tomás-
Autor(es): dc.contributorUniversity of Chile Medical School-
Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.creatorBustos-Obregón, Eduardo-
Autor(es): dc.creatorPoblete, Daniel-
Autor(es): dc.creatorCatriao, Roberto-
Autor(es): dc.creatorFernandes, Fábio Henrique [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:03:31Z-
Data de disponibilização: dc.date.available2022-08-04T22:03:31Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2013-12-03-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.4067/S0717-95022013000300012-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219981-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219981-
Descrição: dc.descriptionArsenic is a testicular environmental toxic. Melatonin (Me), being a potent antioxidant, may reduce the damage caused by arsenic in male fertility. The effects of daily oral exposure of Sodium Arsenite (As; 7.0 mg/kg/bw); Melatonin (Me, 10.0 mg/kg/bw); Me (10.0 mg/kg/bw) plus As (7.0 mg/kg/bw), and Negative Control (NaCl 0.9%) in male CF-1 adult mice were assessed in acute (8.3 days), chronic (33.2 days) and recovery (66,4 days) of testicular damage. We evaluated changes in testicular weight and histopathological, morphometric measurements, expression of COX-2 and Androgen Receptor (AR) antigens and lipid peroxidation levels. Treatment resulted in decreased tubular diameter and AR expression, and increased: interstitial area, luminal diameter, COX-2 expression levels and of lipid peroxidation. Co-administration of As and Me partially decreased germ cell degeneration and AR expression levels, improving testicular histopathological parameters. These results indicate that As causes toxicity and testicular germ cell degeneration by induction of oxidative stress. Me partially protects from this damage in mouse testis, acting as scavenger of oxygen radical species.-
Descrição: dc.descriptionVID Universidad de La Frontera, Temuco-
Descrição: dc.descriptionVeterinary School University Santo Tomás, Santiago-
Descrição: dc.descriptionUniversity of Chile Medical School, Santiago-
Descrição: dc.descriptionSão Paulo State University, Botucatu-
Descrição: dc.descriptionSão Paulo State University, Botucatu-
Formato: dc.format849-856-
Idioma: dc.languageen-
Idioma: dc.languagees-
Relação: dc.relationInternational Journal of Morphology-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAndrogen receptor-
Palavras-chave: dc.subjectArsenic-
Palavras-chave: dc.subjectCOX-2-
Palavras-chave: dc.subjectMelatonin-
Palavras-chave: dc.subjectMouse-
Palavras-chave: dc.subjectOxidative stress-
Título: dc.titleRol protector de la melatonina en el daño de la espermatogénesis en ratón producido por arsenito de sodio-
Título: dc.titleProtective role of melatonin in mouse spermatogenesis induced by sodium arsenite-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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