High genetic diversity among Pseudomonas aeruginosa and Acinetobacter spp. isolated in a public hospital in Brazil

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Autor(es): dc.contributorUniversidade Estadual Paulista (UNESP)-
Autor(es): dc.contributorState University of Maringá-
Autor(es): dc.creatorDias Siqueira, Vera Lúcia [UNESP]-
Autor(es): dc.creatorCardoso, Rosilene Fressatti [UNESP]-
Autor(es): dc.creatorde Pádua, Rubia Andreia Falleiros [UNESP]-
Autor(es): dc.creatorCaleffi-Ferracioli, Katiany Rizzieri [UNESP]-
Autor(es): dc.creatorHelbel, Cesar-
Autor(es): dc.creatorBarreto Santos, Adolfo Carlos [UNESP]-
Autor(es): dc.creatorAoki, Elisabeth Eyko-
Autor(es): dc.creatorNakamura, Celso Vataru [UNESP]-
Data de aceite: dc.date.accessioned2022-08-04T22:03:16Z-
Data de disponibilização: dc.date.available2022-08-04T22:03:16Z-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2022-04-28-
Data de envio: dc.date.issued2013-01-01-
Fonte completa do material: dc.identifierhttp://dx.doi.org/10.1590/S1984-82502013000100006-
Fonte completa do material: dc.identifierhttp://hdl.handle.net/11449/219904-
Fonte: dc.identifier.urihttp://educapes.capes.gov.br/handle/11449/219904-
Descrição: dc.descriptionIn Brazil and other regions of the world, Pseudomonas aeruginosa and Acinetobacter spp. have emerged as important agents of nosocomial infection and are commonly involved in outbreaks. The main objective of the present study was to evaluate the genetic relationship among P. aeruginosa and Acinetobacter spp. isolated from patients in a public university hospital in northwestern Paraná, Brazil, and report their antimicrobial resistance profile. A total of 75 P. aeruginosa and 94 Acinetobacter spp. isolates were phenotypically identified and tested for antibiotic susceptibility using automated methodology. Polymyxin B was tested by disk diffusion for P. aeruginosa. Metallo-b-lactamase (MBL) was detected using a disk approximation test. Genotyping was performed using enterobacterial repetitive intergenic consensus polymerase chain reaction (ERIC-PCR). Approximately 55% of the P. aeruginosa isolates and 92% of the Acinetobacter spp. isolates were multiresistant, but none were MBL-producers. ERIC-PCR revealed the presence of small clusters of carbapenem-resistant Acinetobacter spp., most likely OXA-type carbapenemase producers. Furthermore, high genetic diversity in P. aeruginosa and Acinetobacter spp. clinical isolates was observed, suggesting that cross-transmission is not very frequent in the studied hospital.-
Descrição: dc.descriptionDepartment of Biological Science School of Pharmaceutical Science Paulista State University-
Descrição: dc.descriptionDepartment of Clinical Analysis and Biomedicine School of Pharmaceutical Science Paulista State University-
Descrição: dc.descriptionUniversity Hospital of Maringá State University of Maringá-
Descrição: dc.descriptionLaboratory of Mycobacteriology, Department of Biological Science School of Pharmaceutical Science Paulista State University-
Descrição: dc.descriptionDepartment of Biological Science School of Pharmaceutical Science Paulista State University-
Descrição: dc.descriptionDepartment of Clinical Analysis and Biomedicine School of Pharmaceutical Science Paulista State University-
Descrição: dc.descriptionLaboratory of Mycobacteriology, Department of Biological Science School of Pharmaceutical Science Paulista State University-
Formato: dc.format49-56-
Idioma: dc.languageen-
Relação: dc.relationBrazilian Journal of Pharmaceutical Sciences-
???dc.source???: dc.sourceScopus-
Palavras-chave: dc.subjectAcinetobacter spp./antimicrobial resistance profile-
Palavras-chave: dc.subjectAcinetobacter spp./genetic study-
Palavras-chave: dc.subjectAntimicrobial resistance-
Palavras-chave: dc.subjectBacterial typing-
Palavras-chave: dc.subjectPseudomonas aeruginosa/antimicrobial resistance profile-
Palavras-chave: dc.subjectPseudomonas aeruginosa/genetic study-
Título: dc.titleHigh genetic diversity among Pseudomonas aeruginosa and Acinetobacter spp. isolated in a public hospital in Brazil-
Tipo de arquivo: dc.typelivro digital-
Aparece nas coleções:Repositório Institucional - Unesp

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